Sensitization of X-Irradiated Chinese Hamster V79 Cells by Derivatives of Pyrimidine Nucleosides

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概要

• 論文の詳細を見る

• The modification of the lethal effects of ionizing radiation on cultured mammalian cells by the pyrimidine nucleoside analogues, 3'-azido-2', 3'-dideoxythymidine, 3'-amino-2', 3'-dideoxythymidine, 2', 3'-didehydro-2', 3'-dideoxythymidine and 2', 3'-didehydro-2', 3'-dideoxycytidine, was investigated using X-irradiated log-phase Chinese hamster V79 cells. The exposure of the cells to these drugs (1-7.5 mM) for 3h after X irradiation reduced the cell survival. The killing efficiency was further enhanced by treating the cells with the drugs for 3h befbre X irradiation and continuing the treatment for 3h after X irradiation. These observations reveal that the nucleoside analogues, which are known as inhibitors of human immunodeficiency virus replication, have the ability to suppress cellular recovery from the radiation-induced potentially lethal state of X-irradiated cells.

• 日本放射線影響学会の論文

著者

• Matsuda A

  Hokkaido Univ. Sapporo Jpn

• Tanabe Kiyoshi

  富山医科薬科大学 放射線基礎医

• Sato F

  Japan Racing Assoc. Utsunomia

• Sato Fumiaki

  Faculty Of Veterinary Medicine Hokkaido Univ.

• MATSUDA Akira

  Faculty of Pharmaceutical Sciences, Hokkaido University

• UEDA TOHRU

  Faculty of Pharmaceutical Sciences, Hokkaido University

• KUWABARA Mikinori

  Faculty of Veterinary Medicine, Hokkaido University

• HIRAOKA Wakako

  Faculty of Veterinary Medicine, Hokkaido University

• TANABE KIYOSHI

  Faculty of Veterinary Medicine, Hokkaido University

• Matsuda Akira

  The Department Of Internal Medicine Kin-ikyo Chuo Hospital

• Sato F

  Equine Research Institute

• Ueda T

  Faculty Of Pharmaceutical Science Hokkaido University

• Hiraoka W

  Department Of Physics School Of Science And Technology Meiji University

• Sato F

  Hokkaido Univ. Sapporo

• Matsuda Akira

  Faculty Of Pharmaceutical Sciences Hokkaido University

• Sato Fumiaki

  Faculty Of Information Shizuoka University

• Ueda Tohru

  Faculty Of Bioresource Sciences Akita Prefectural University

• Sato Fumiaki

  Faculty of Engineering, Shizuoka University

• TANABE Kiyoshi

  Dept. Radiol. Sci., Toyama Medical and Pharmaceutical Univ.

• TANABE Kiyoshi

  Department of Physics, Kagoshima University

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