In Vitro and in Vivo Antitumor Activity of a Novel Nucleoside, 4'-Thio-2'-deoxy-2'-methylidenecytidine

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概要

• 論文の詳細を見る

• The in vitro and in vivo antitumor activity of a novel nucleoside, 4'-thio-2'-deoxy-2'-methylidenecytidine (4'-thio-DMDC), was examined. 4'-Thio-DMDC inhibited the growth of various cell established from human solid cancers, particularly the growth of lung and bladder carcinomas and melanomas. 4'-Thio-DMDC exhibited potent antitumor activity against subcutaneously implanted murine sarcoma S-180 and human fibrosarcoma HT-1080 xenografts. It was shown that 4'-thio-DMDC suppressed cell growth by inhibiting cellular DNA synthesis, and phosphorylation of the 5'-position of its deoxyribose by deoxycytidine kinase was needed for its antitumor activity. 4'-Thio-DMDC is a poor substrate for cytidine deaminase, thus it is a promising agent for the treatment of malignant solid tumors because it will not be converted into its inactive uridine form.

• 社団法人日本薬学会の論文
• 1996-10-15

著者

• 田中 正一

  Graduate School Of Pharmaceutical Sciences Kyushu University

• Tanaka M

  Faculty Of Pharmaceutical Sciences Tokushima Bunri University

• MIURA Shinji

  Department of Ophthalmology and Visual Sciences, Kyoto University Graduate School of Medicine

• MATSUDA Akira

  Faculty of Pharmaceutical Sciences, Hokkaido University

• SASAKI Takuma

  Department of Experimental Therapeutics, Kanazawa University Cancer Research Institute

• TANAKA Motohiro

  Department of Experimental Therapeutics, Kanazawa University Cancer Research Institute

• Matsuda A

  Graduate School Of Pharmaceutical Sciences Hokkaido University

• Matsuda A

  Faculty Of Pharmaceutical Sciences Hokkaido University

• YOSHIMURA Yuichi

  Research and Development Division, Yamasa Corporation

• SATOH Hiroshi

  Research and Development Division, Yamasa Corporation

• SAKATA Shinji

  Research and Development Division, Yamasa Corporation

• MACHIDA Haruhiko

  Research and Development Division, Yamasa Corporation

• Yoshimura Y

  Department Of Analytical Chemistry Hoshi University

• Sakata S

  Research And Development Division Yamasa Corporation

• Machida Haruhiko

  Research And Development Division Yamasa Corporation

• Miura S

  Yamasa Corp. Chiba Jpn

• Yoshimura Yuichi

  Biochemicals Division Yamasa Corporation

• Yoshimura Yuichi

  School Of Pharmaceutical Sciences Showa University

• Sakata Shinji

  Research And Development Division Yamasa Corporation

• Matsuda Akira

  The Department Of Internal Medicine Kin-ikyo Chuo Hospital

• Miura Shinji

  Department Of Ophthalmology And Visual Sciences Kyoto University Graduate School Of Medicine

• Sasaki Takuma

  Department Of Experimental Therapeutics Cancer Research Insitute Kanazawa University

• SATOH Hiroshi

  Biochemicals Division, Yamasa Corporation

• Tanaka Motohiro

  Department Of Experimental Therapeutics Cancer Reserch Institute Kanazawa University

• Matsuda Akira

  Faculty Of Pharmaceutical Sciences Hokkaido University

• Satoh H

  Biochemicals Division Yamasa Corporation

• Miura Shinji

  Department Of Applied Biological Science Tokyo Noko University

• Sasaki Takuma

  Department Of Expenmental Therapeutlcs Cancer Research Institute Kanazawa University

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