EFFECT OF SERUM FROM MICE TREATED WITH ANTITUMOR POLYSACCHARIDE ON EXPRESSION OF CYTOTOXICITY BY MOUSE PERITONEAL MACROPHAGES

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概要

• 論文の詳細を見る

• Treatment of ICR mice i.p. with the antitumor polysaccharide (1→3)-β-D-glucan (TAK-N) or its carboxymethylderivative (CM-glucan) rendered macrophages cytotoxic to L5178Y lymphoma cells in vitro. The ability of macrophages to inhibit tumor cell proliferation appeared on days 4 and 9 after the injections of TAK-N and CM-glucan, respectively. Peritoneal macrophages from normal untreated mice were not cytotoxic. On in vitro incubation with serum from mice treated with the glucans, peritoneal macrophages from normal untreated mice became cytotoxic to tumor cells. This activating effect appeared transitorily in the serum on days 2-4 and 9-10 after administrations of TAK-N and CM-glucan, respectively, to mice. Neither the glucans alone, nor serum from untreated mice induced cytotoxicity of normal mouse peritoneal macrophages in vitro. On fractionation of mouse serum obtained on day 4 after injection of TAK-N at a dose of 80 mg/kg, two in vitro activators of normal macrophage were obtained : one was a peptide (mol.wt., 4,500 daltons), and the other was probably a peptidoglycan (mol.wt., 9000 daltons).

• 公益社団法人日本薬学会の論文

著者

• 田中 正一

  Graduate School Of Pharmaceutical Sciences Kyushu University

• Tanaka M

  Faculty Of Pharmaceutical Sciences Tokushima Bunri University

• Uchida Hiroyuki

  Faculty Of Engineering Fukui University

• SASAKI TAKUMA

  Chemotherapy Division, National Cancer Center Research Institute

• UCHIDA HIROYUKI

  Chemotherapy Division, National Cancer Center Research Institute

• TANAKA MOTOHIRO

  Chemotherapy Division, National Cancer Center Research Institute

• Uchida H

  Department Of Physics Kyushu University

• Sasaki Takuma

  Chemotherapy Division National Cancer Center Research Institute

• Sasaki Takuma

  Department Of Experimental Therapeutics Cancer Research Insitute Kanazawa University

• Uchida Hiroyuki

  Chemotherapy Division National Cancer Center Research Institute

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