Solid-State Conformation of a Hybrid Tripeptide between β-Amino Acid ; 8-Aminocyclooct-4-enecarboxylic Acid and 2-Aminoisobutyric Acid

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概要

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• An eight-membered cyclic β-amino acid, 8-aminocyclooct-4-enecarboxylic acid, was designed as a conformationally restricted non-proteinogenic amino acid. A hybrid tripeptide containing this eight-membered cyclic β-amino acid and 2-aminoisobutyric acids was synthesized by conventional solution methods. The conformation of the tripeptide was studied using X-ray analysis and was shown to form an eleven-membered hydrogen-bonded turn (3_11-helical structure) in the solid state.

• 社団法人日本薬学会の論文
• 2001-09-01

著者

• 田中 正一

  Graduate School Of Pharmaceutical Sciences Kyushu University

• TANAKA Masakazu

  Graduate School of Pharmaceutical Sciences, Kyushu University

• SUEMUNE Hiroshi

  Graduate School of Pharmaceutical Sciences, Kyushu University

• OBA Makoto

  Graduate School of Pharmaceutical Sciences, Kyushu University

• ICHIKI Takaharu

  Graduate School of Pharmaceutical Sciences, Kyushu University

• Ichiki Takaharu

  Graduate School Of Pharmaceutical Sciences Kyushu University

• Oba Makoto

  Graduate School Of Information Shizuoka University

• Suemune H

  Graduate School Of Pharmaceutical Sciences Kyushu University

• Suemune Hiroshi

  Graduate School Of Pharmaceutical Sciences Kyushu University

• Tanaka Masakazu

  Graduate School Of Comprehensive Human Sciences University Of Tsukuba

• Oba Makoto

  Graduate School Of Biomedical Sciences Nagasaki University

• TANAKA Masakazu

  Graduate School of Agriculture, Hokkaido University

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