Novel Abietane Diterpenoids and Aromatic Compounds from Cladonia rangiferina and Their Antimicrobial Activity against Antibiotics Resistant Bacteria

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概要

• 論文の詳細を見る

• From Cladonia rangiferina were isolated two novel abietane diterpenoids, hanagokenols A (1) and B (2). Also in this investigation, four known abitetane diterpenoids (3-6), four known labdane diterpenoids (7-10), one known isopimarane diterpenoid (11), and six known aromatic compounds were isolated. These structures were elucidated primarily through extensive NMR experiments. Hanagokenol A (1) was a unique abietane diterpene having an ether linkage between C-6 and C-18 of sugiol. Hanagokenol B (2) is also a unique secoabietane diterpene, having γ-lactone which occurred by cleavage and subsequently oxidation between C-6/C-7 of 12-hydroxy-dehydroabietinol. Furthermore, all the isolated compounds (1-17) were tested for the antimicrobial activity against methicillin-resistant Staphylococcus aureus (MRSA) and vancomycin-resistant Enterococci (VRE).

• 公益社団法人日本薬学会の論文
• 2008-01-01

著者

• 田中 正一

  Graduate School Of Pharmaceutical Sciences Kyushu University

• HASHIMOTO Toshihiro

  Faculty of Pharmaceutical Sciences, Tokushima Bunri University

• Tanaka Muneo

  Research Center Shiseido Ltd.

• Tanaka M

  Faculty Of Pharmaceutical Sciences Tokushima Bunri University

• 田中 誠

  School Of Pharmaceutical Sciences Kitasato University

• TANAKA Masami

  Faculty of Pharmaceutical Sciences, Tokushima Bunri University

• SHIBATA Hirofumi

  Faculty of Pharmaceutical Sciences, The University of Tokushima

• YOSHIKAWA Kazuko

  Faculty of Pharmaceutical Sciences, Tokushima Bunri University

• KOKUDO Naoki

  Faculty of Pharmaceutical Sciences, Tokushima Bunri University

• NAKANO Tatsuro

  Faculty of Pharmaceutical Sciences, Tokushima University

• ARAGAKI Naokatsu

  Faculty of Pharmaceutical Sciences, Tokushima University

• HIGUCHI Tomihiko

  Faculty of Pharmaceutical Sciences, Tokushima University

• Nakano Tatsuro

  Faculty Of Pharmaceutical Sciences Tokushima University

• Hashimoto Toshihiro

  Faculty Of Pharmaceutical Sciences Tokushima Bunri University

• Shibata Hirofumi

  Faculty Of Pharmaceutical Sciences Tokushima University

• Yoshikawa K

  Faculty Of Pharmaceutical Sciences Tokushima Bunri University

• Yoshikawa Kazuko

  Faculty Of Pharmaceutical Sciences Tokushima Bunri University

• Aragaki Naokatsu

  Faculty Of Pharmaceutical Sciences Tokushima University

• Tanaka M

  Nihon Univ. Fujisawa‐shi Jpn

• Kokudo Naoki

  Faculty Of Pharmaceutical Sciences Tokushima Bunri University

• Higuchi Tomihiko

  Faculty Of Pharmaceutical Sciences Tokushima University

• Tanaka Masami

  Faculty Of Pharmaceutical Sciences Tokushima Bunri University

• Higuchi Tomihiko

  Faculty Of Pharmaceutical Science Tokushima University

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