Sesquiterpenoids Isolated from Eupatorium glehnii. Isolation of Guaiaglehnin A, Structure Revision of Hiyodorilactone B, and Genetic Comparison

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概要

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• A new sesquiterpenoid substituted with unsaturated ester, guaiaglehnin A (1), along with 15 previously known compounds, were isolated from the methanol extract of the terrestrial part of Eupatorium glehnii (Compositae) collected in Nagano Prefecture, Japan, the results of which supported the previous study by Takahashi et al. The chemical constituents of E. glehnii collected in Nagano Prefecture and those collected in Tokushima or Hokkaido are quite different, depending on collection site, although the species are identical. The base sequences of three different samples were identical. Diversity in the chemical components was detected, though no diversity existed in the DNA sequence. In this study, eupasimplicin A (2) was also isolated, whose presence in the extract of E. chinense simplicifolium was recorded but not in an article. The side chain geometry of hiyodorilactone B (5) was revised to be E.

• 公益社団法人日本薬学会の論文
• 2008-05-01

著者

• 通 元夫

  徳島文理大薬

• HIROTA Naoko

  Faculty of Human Health Science, Matsumoto University

• Hirota Hiroshi

  RIKEN Genomic Sciences Center

• Hirota Naoko

  Faculty Of Human Health Science Matsumoto University

• Hirota Naoko

  Faculty Of Pharmaceutical Sciences Tokushima Bunri University

• Sato Masao

  徳島文理大学 薬学部

• TANAKA Masami

  Faculty of Pharmaceutical Sciences, Tokushima Bunri University

• Sono M

  Faculty Of Pharmaceutical Sciences Tokushima Bunri University

• TORI Motoo

  Faculty of Pharmaceutical Sciences, Tokushima Bunri University

• Tori M

  Faculty Of Pharmaceutical Sciences Tokushima Bunri University

• Tori Motoo

  Faculty Of Pharmaceutical Sciences Tokushima Bunri University

• MORISHITA Norie

  Faculty of Pharmaceutical Sciences, Tokushima Bunri University

• SAITO Yoshinori

  Faculty of Pharmaceutical Sciences, Tokushima Bunri University

• NAKASHIMA Katsuyuki

  Faculty of Pharmaceutical Sciences, Tokushima Bunri University

• SONO Masakazu

  Faculty of Pharmaceutical Sciences, Tokushima Bunri University

• UTAGAWA Akiko

  Tama University Hijirigaoka High School

• Sono Masakazu

  Faculty Of Pharmaceutical Sciences Tokushima Bunri University

• Nakashima K

  Faculty Of Pharmaceutical Sciences Tokushima Bunri University

• Nakashima Katsuyuki

  Faculty Of Pharmaceutical Sciences Tokushima Bunri University

• Morishita Norie

  Faculty Of Pharmaceutical Sciences Tokushima Bunri University

• Tanaka Masami

  Faculty Of Pharmaceutical Sciences Tokushima Bunri University

• Saito Yoshinori

  Faculty Of Pharmaceutical Sciences Tokushima Bunri University

• Hirota Hiroshi

  Riken

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