Classical Conditioning of Metallothionein Synthesis in Mice
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概要
- 論文の詳細を見る
To clarify the role of metallothionein (MT), an anti-stress protein, induced by psychological stress, we carried out an experiment to determine whether hepatic MT synthesis induced by restraint stress can be classically conditioned by an olfactory odor cue of camphor. Mice were conditioned by exposure to the odor of camphor 1 hr before restraint stress and partly during restraint stress. Although exposure to the odor of camphor did not elevate hepatic MT levels in itself, the odor stimuli significantly elevated hepatic MT levels in mice conditioned for 3 days. The results indicate that MT synthesis is induced by an association of the central nervous system with psychological stress.
- 公益社団法人日本薬学会の論文
- 2004-08-01
著者
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Sato Masao
Faculty of Pharmaceutical Science, Tokushima Bunri University
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近藤 昌夫
Graduate School Of Pharmaceutical Sciences Osaka Univ.
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Watanabe Yoshiteru
Department of Pharmaceutics and Biopharmaceutics, Showa Pharmaceutical University
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Sato Masao
徳島文理大学 薬学部
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KONDOH Masuo
Department of Biopharmaceutics and Pharmaceutics, Showa Pharmaceutical University
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Watanabe Yoshiteru
Department Of Pharmaceutics And Biopharmaceutics Showa Pharmaceutical University
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Kodama Daisuke
Graduate School Of Pharmaceutical Sciences Osaka University
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Kodama Daisuke
Department Of Materials Chemistry And Engineering College Of Engineering Nihon University
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Kodama Daisuke
Faculty Of Pharmaceutical Sciences Tokushima Bunri University
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Kondoh Masuo
Faculty Of Pharmaceutical Sciences Tokushima Bunri University
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Sato Masao
Faculty Of Pharmaceutical Science Tokushima Bunri University
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