Effect of Particle Size of Drug on Conversion of Crystals to an Amorphous State in a Solid Dispersion with Crospovidone
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概要
- 論文の詳細を見る
The effect of particle size on amorphization of drugs in a solid dispersion (SD) was investigated for two drugs, indomethacin (IM) and nifedipine (NP). The SD of drugs were prepared in a mixture with crospovidone by a variety of mechanical methods, and their properties investigated by particle sizing, thermal analysis, and powder X-ray diffraction. IM, which had an initial particle size of 1 μm and tends to aggregate, was forced through a sieve to break up the particles. NP, which had a large initial particle size, was jet-milled. In both cases, reduction of the particle size of the drugs enabled transition to an amorphous state below the melting point of the drug. The reduction in particle size is considered to enable increased contact between the crospovidone and drug particles, increasing interactions between the two compounds.
著者
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KOIZUMI Naoya
Department of Radiology, Niigata University School of Medicine
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Sugamura Yuka
Department of Pharmaceutics and Biopharmaceutics, Showa Pharmaceutical University
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Fujii Makiko
Department of Pharmaceutics and Biopharmaceutics, Showa Pharmaceutical University
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Nakanishi Sayaka
Department of Pharmaceutics and Biopharmaceutics, Showa Pharmaceutical University
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Suzuki Ayako
Department of Pharmaceutics and Biopharmaceutics, Showa Pharmaceutical University
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Shibata Yusuke
Department of Pharmaceutics and Biopharmaceutics, Showa Pharmaceutical University
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Watanabe Yoshiteru
Department of Pharmaceutics and Biopharmaceutics, Showa Pharmaceutical University
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Fujii Makiko
Showa Pharmaceutical Univ.
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Fujii Makiko
Department Of Chemistry Faculty Of Engineering Gifu University
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Fujii M
Department Of Pharmaceutics And Biopharmaceutics Showa Pharmaceutical University
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Watanabe Yoshiteru
Department Of Pharmaceutics And Biopharmaceutics Showa Pharmaceutical University
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Shibata Yusuke
Department Of Informatics Kyushu University:present Address Ntt Comware
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Fujii M
Showa Univ. Tokyo Jpn
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Koizumi Naoya
Department Of Bioengineering Tokyo Institute Of Technology
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Suzuki Ayako
Department Of Molecular Cytogenetics Medical Research Institute And School Of Biomedical Science Tok
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Koizumi Naoya
Department of Pharmaceutics and Biopharmaceutics, Showa Pharmaceutical University
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SUZUKI Ayako
Department of Gynecology and Obstetrics, Kyoto University Graduate School of Medicine
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