Alterations in Cardiac β-Adrenoceptors During the Development of RatExperimental Autoimmune Myocarditis

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概要

• 論文の詳細を見る

• In this study, we investigated changes in cardiac β-adrenoceptor densities (Bmax) and affinities (dissociation constant : Kd) by Scachard analysis using the radioligand binding assay method during the development of rat experimental autoimmune myocarditis (EAM). Rats at 11 weeks of age were subcutaneously injected in both foodpads with 0.2ml of antigen-adjuvant emulsion for the induction of EAM. A peak increase in Bmax values of cardiac muscles of EAM was observed at day 18 (active phase), followed by a tendency to decrease until day 214 after immunization. However, there were no changes in Kd values at any stage of EAM. Thus, the present study indicates that β-AR densities change according to the stages of EAM.

• 新潟大学の論文

著者

• Aizawa Yoshiyasu

  神戸大学 医学部

• Hirono S

  Niigata Univ. Graduate School Of Medicine And Dental Sci. Niigata Jpn

• Kenichi WATANABE

  Department of Clinical Pharmacology, Niigata College of Pharmacy

• Toshio Ohnuki

  Department Of Pharmacology Niigata University School Of Medicine

• Takashi NAKAMURA

  Department of Pharmacology, Niigata College of Pharmacy

• Ohnuki Toshio

  Department Of Pharmacology Faculty Of Pharmaceutical Sciences Hokkaido University

• Ayako SUZUKI

  Department of Pharmacology, Niigata University School of Medicine

• Suzuki Ayako

  Department Of Molecular Cytogenetics Medical Research Institute And School Of Biomedical Science Tok

• Ayako Suzuki

  Department Of Pharmacology Niigata University School Of Medicine

• Nakamura Takashi

  Department Of Cardiology Saiseikai Shiga Hospital

• Watanabe Koji

  Division Of Hepatology And Gastroenterology Niigata University Graduate School Of Medical And Dental

• SUZUKI Ayako

  Department of Gynecology and Obstetrics, Kyoto University Graduate School of Medicine

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