Prevalence of Coronary Artery Disease in Japanese Patients With Cerebral Infarction : Impact of Metabolic Syndrome and Intracranial Large Artery Atherosclerosis
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概要
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Background Patients with cerebral infarction have a high prevalence of asymptomatic coronary artery disease (CAD) and other vascular diseases, but there is a lack of such data for Japanese patients, so the present study investigated the prevalence of cardiovascular disease (CVD) in Japanese patients and determined the predictors of CAD. Methods and Results The study group comprised 104 patients with cerebral infarction who had no history of CVD. All patients underwent coronary computed tomographic angiography, and systematic evaluation was done on the basis of the presence of other vascular diseases, CVD risk markers, and the degree of atherosclerosis. Of the total, 39 patients (37.5%) had CAD, 9 (8.7%) had carotid artery stenosis, 9 (8.7%) had peripheral artery disease of the lower limbs, and 3 (2.9%) had atherosclerotic renal artery stenosis. Multiple regression analysis showed that the presence of CAD was independently associated with metabolic syndrome (odds ratio (OR) 5.008, 95% confidence interval (CI) 1.538-16.309; p<0.01) and intracranial large artery atherosclerosis (OR 4.979, 95% CI 1.633-15.183; p<0.01). Conclusion Japanese patients with cerebral infarction have a high prevalence of CVD, especially asymptomatic CAD. Both metabolic syndrome and intracranial large artery atherosclerosis may be potential predictors for identifying patients with cerebral infarction who are at the highest risk of asymptomatic CAD.
- 社団法人日本循環器学会の論文
- 2008-02-20
著者
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Nakahara Yoshifumi
Department of Cardiology, Saiseikai Shigaken Hospital
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Nakamura Takashi
Department of Cardiology, Saiseikai Shigaken Hospital
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Kurata Hiroyuki
Department of Bioscience and Bioinformatics, Kyushu Institute of Technology
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ENOMOTO Satoko
Department of Cardiovascular Medicine, Nantan General Hospital
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Hoshino Atsushi
Department of Cardiovascular Medicine, Kyoto Prefectural University of Medicine
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Kawahito Hiroyuki
Department Of Cardiology Saiseikai Shigaken Hospital
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Nakamura T
Second Department Of Internal Medicine Kyoto Prefectural University Of Medicine
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Hoshino Atsushi
Department Of Cardiology Kyoto Prefectural University Of Medicine
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Ijichi Toshiharu
Saiseikai Shiga Hospital, Neurology
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Nakahara Yoshihumi
Department of Cardiology, Saiseikai Shiga Hospital
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Kurata Hiroyuki
Department Of Bioscience And Bioinformatics Kyushu Institute Of Technology
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Nakahara Yoshihumi
Department Of Cardiology Saiseikai Shiga Hospital Imperial Gift Foundation Inc.
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Nakahara Yoshifumi
Department Of Cardiology Saiseikai Shigaken Hospital
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Nakahara Yoshifumi
Department Of Cardiology Saiseikai Shiga Hospital
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Enomoto Seiko
Department Of Cardiology Kyoto Prefectural University Of Medicine
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Enomoto Satoko
Department Of Cardiovascular Medicine Nantan General Hospital
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Kurata Hiroyuki
Department Of Cardiology Saiseikai Shigaken Hospital
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Ijichi Toshiharu
Saiseikai Shiga Hospital Neurology:(present Office) Ijichi Clinic
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Nakamura Takashi
Department Of Cardiology Saiseikai Shiga Hospital
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Kawahito Hiroyuki
Department Of Cardiology Saiseikai Shiga Hospital Imperial Gift Foundation Inc.
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