Internalization of Constitutively Active N111G Mutant of AT1 Receptor Induced by Angiotensin II–Receptor Antagonists Candesartan, Losartan, and Telmisartan: Comparison With Valsartan
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概要
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Based on radioligand binding and signal transduction assays in our previous study, we have determined the binding pattern and functional efficacy of the constitutively active mutant N111G of angiotensin II type 1 (AT1) receptor. We have also shown that the N111G mutant induces homologous internalization through mediation of the AT1-receptor antagonist valsartan. In this study we demonstrated that other AT1-receptor antagonists, candesartan, losartan, and telmi-sartan, also stimulate internalization of N111G mutant receptor to the same extent. We further showed that the internalization pattern is also similar for all the AT1-receptor antagonists.
- 社団法人 日本薬理学会の論文
著者
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Nakamura Takashi
Department of Cardiology, Saiseikai Shigaken Hospital
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Ozaki Masanobu
Department of Toxicology, Niigata University of Pharmacy and Applied Life Science
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BHUIYAN Mohiuddin
Department of Pharmacology, Niigata University of Pharmacy and Applied Life Sciences
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HOSSAIN Murad
Department of Pharmacology, Niigata University of Pharmacy and Applied Life Sciences
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NAGATOMO Takafumi
Department of Pharmacology, Niigata University of Pharmacy and Applied Life Sciences
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長友 孝文
新潟薬科大学薬学部薬理学教室
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Ozaki Masanobu
Department Of Cardiology Fukuoka University School Of Medicine
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Nagatomo T
Dep. Of Pharmacology Fac. Of Pharmaceutical Sciences Niigata Univ. Of Pharmacy And Applied Life Scie
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Nagatomo Takafumi
Department Of Pharmacology Faculty Of Pharmaceutical Sciences Niigata University Of Pharmacy And App
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Bhuiyan Mohiuddin
Department Of Pharmacology Faculty Of Pharmaceutical Sciences Niigata University Of Pharmacy And App
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Hossain Murad
Department Of Pharmacology Faculty Of Pharmaceutical Sciences Niigata University Of Pharmacy And App
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Nakamura Takashi
Department Of Cardiology Saiseikai Shiga Hospital
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Hossain Murad
Department of Pharmacology, Faculty of Pharmaceutical Sciences, Niigata University of Pharmacy and Applied Life Sciences, Japan
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Nagatomo Takafumi
Department of Pharmacology, Faculty of Pharmaceutical Sciences, Niigata University of Pharmacy and Applied Life Sciences, Japan
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Bhuiyan Mohiuddin
Department of Pharmacology, Faculty of Pharmaceutical Sciences, Niigata University of Pharmacy and Applied Life Sciences, Japan
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