Preparation and Evaluation of Heat-sensitive Melting Gel : Acetaminophen Gel
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概要
- 論文の詳細を見る
The aim of the present study was to prepare a heat-sensitive melting gel using κ-carrageenan and gelatin as the gelation agents. The two agents have similar melting points (40〜50℃ for κ-carrageenan and 20〜30℃ for gelatin). When mixed together, they have a coexisting grid structure, which is favorable for the preparation of a gel with a melting temperature close to the human body temperature. Gel preparation showed a clearly different melting behavior from that of many other compounds and began to soften significantly below its melting temperature. κ-carrageenan at 0.5% may thus be the preferred concentration because preparations having a melting temperature just below the human body temperature are easy to chew, with a rapidly decreasing viscosity. We studied the plasma concentrations of acetaminophen as a function of time after the oral administration of a bulk powder or gel preparation of acetaminophen to rabbits after overnight fasting. A comparison of the AUC for both oral and intravenous administration indicated the bioavailability of acetaminophen gel to be about 90%. The heat-sensitive acetaminophen melting gel prepared using κ-carrageenan and gelatin thus shows promise for clinical use because of its favorable physicochemical and pharmaceutical characteristics.
- 日本医療薬学会の論文
- 2000-06-10
著者
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Watanabe Yoshiteru
Department of Pharmaceutics and Biopharmaceutics, Showa Pharmaceutical University
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ENDO Hisashi
Department of Medical Oncology, Comprehensive Cancer Center, Saitama Medical University
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Endo H
Department Of Pharmacy Yokohama City University Hospital
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Endo Hisashi
Department Of Medical Oncology Comprehensive Cancer Center Saitama Medical University
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Matsumoto Mitsuo
Department of Pharmaceutics, Showa Pharmaceutical University
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SHIROTAKE Shoichi
Department of Pharmacy, Yokohama City University Hospital
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Watanabe Yoshiteru
Department Of Pharmaceutics And Biopharmaceutics Showa Pharmaceutical University
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Shirotake Shoichi
Department Of Pharmaceutics And Biopharmaceutics Showa Pharmaceutical University
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Matsumoto Mitsuo
Department Of Pharmaceutics Showa Pharmaceutical University
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Murata Masahiro
Department Of Pharmacy Services Tama Nagayama Hospital Nippon Medical School
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Watanabe Yoshiteru
Showa Pharmaceutical Univ.
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Endo H
Department Of Drug Metabolism Research Center Taisho Pharmacetutical Co. Ltd.
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Matsumoto Mitsuo
Department Of Pharmaceutics And Biopharmaceutics Showa Pharmaceutical University
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Shiraishi Shuji
Department Of Pharmaceutics And Biopharmaceutics Showa Pharmaceutical University
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Matsumoto Mitsuo
Department Of Ophthalmology Hirosaki University School Of Medicine
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ENDO HISASHI
Department of Internal Medicine, National Shikoku Cancer Center
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Matsumoto Mitsuo
Department of Hydrocarbon Chemistry, Faculty of Engineering, Kyoto University
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