Studies of Drug Delivery Systems for a Therapeutic Agent Used in Osteoporosis. II. Enhanced Absorption of Elcatonin from Nasal Mucosa in Rabbits

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概要

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• In this study, the effects of a protease inhibitor, endocytosis inhibitors and an absorption-enhancing agent on the absorption of (Asu^<1,7>)-eel calcitonin, ECT) from the nasal mucous membrane in rabbits were examined, and the results were compared with those obtained following the rectal absorption of ECT reported in our previous paper. ECT was efficiently absorbed from the nasal mucous membrane and effectively decreased serum calcium (Ca) concentrations. The increase in the area under the precent decrease in serum Ca concentration (ΔCa%)-time curve (ΔCa%-AUC) value, assumed to be an index of the pharmacodynamics (hypocalcemic effect) of ECT, depended on the dose of ECT administered intranasally. When nafamostat mesilate, a protease inhibitor, was coadministered with ECT, the ΔCa%-AUC markedly increased. It is presumed that the influence (enzymatic barrier function) of protease on the nasal absorption of ECT is significant. However, no significant difference in the ΔCa%-AUC value was observed when an endocytosis inhibitor (cytochalasin B or monensin) was coadministered with ECT. ECT administration in combination with sodium decanoate, the sodium salt of a medium-chain fatty acid, effectively increased the ΔCa%-AUC value due to the enhancing effect of sodium decanoate on the nasal absorption of ECT. We conclude that the nasal application offers a promising approach for the administration of pharmaceutical preparations containing ECT with additives such as nafamostat mesiate and sodium decanoate.

• 公益社団法人日本薬学会の論文
• 1998-11-15

著者

• Matsumoto M

  Osaka Medical Center For Cancer And Cardiovascular Diseases Osaka

• Matsumoto Misako

  Department Of Immunology Osaka Medical Center For Cancer And Cardiovascular Diseases

• Watanabe Yoshiteru

  Department of Pharmaceutics and Biopharmaceutics, Showa Pharmaceutical University

• Matsumoto Mitsuo

  Department of Pharmaceutics, Showa Pharmaceutical University

• Matsumoto Mitsuharu

  Takeda Chemical Industries Ltd. Pharmaceutical Research Division

• UTOGUCHI Naoki

  Department of Pharmaceutics and Biopharmaceutics, Showa Pharmaceutical University

• Watanabe Yoshiteru

  Department Of Pharmaceutics And Biopharmaceutics Showa Pharmaceutical University

• Watanabe Y

  Showa Pharmaceutical Univ.

• Matsumoto Mitsuo

  Department Of Pharmaceutics Showa Pharmaceutical University

• Watanabe Yoshiteru

  Showa Pharmaceutical Univ.

• MIZUFUNE Yuko

  Department of Pharmaceutics, Showa College of Pharmaceutical Sciences

• Endo Kazutoyo

  Physical Chemistry Showa College Of Pharmaceutical Sciences

• Utoguchi Naoki

  Department Of Biopharmaceutics School Of Pharmaceutical Sciences Teikyo University

• Matsumoto Mitsuhiro

  First Department Of Internal Medicine Kumamoto University School Of Medicine

• Matsumoto Mitsuo

  Department Of Pharmaceutics And Biopharmaceutics Showa Pharmaceutical University

• Mizufune Yuko

  Department Of Pharmaceutics Showa College Of Pharmaceutical Sciences

• Matsumoto Mitsuo

  Department Of Ophthalmology Hirosaki University School Of Medicine

• Matsumoto Mitsuo

  Department of Hydrocarbon Chemistry, Faculty of Engineering, Kyoto University

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