A New Ultraviolet Protective Agent of the Intercalation Compound of Aminobenzoic Acid Esters (UV Absorber) and Synthetic Mica (Inorganic Layered Compound)

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概要

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• The interaction between a sodium-type synthetic mica (Na-TSM), a material of reactive layered compounds which exhibit characteristic light scattering, and some aminobenzoic acid derivatives which act as UV absorbing agents (UV absorber), was investigated. Due to the observed elongation of interlayer spacing (increase in the d-value) by X-ray diffraction analysis, it was found that the powdered form of 4-aminobenzoic acid ethyl ester (4-ABE) interacts with Na-TSM, and can be immobilized in the interlayer space of Na-TSM. Consequently, an intercalation compound of 4-ABE and Na-TSM was obtained. The formation of the intercalation compound of 4-ABE and Na-TSM was accelerated by heat processing, particularly at temperatures exceeding the melting point of 4-ABE. When 2-aminobenzoic acid methyl ester (2-ABM) in liquid form at room temperature was used instead of 4-ABE, the intercalation compound of 2-ABM and Na-TSM was formed in a similar manner to that of 4-ABM and Na-TSM. The heat processing again accelerated the formation of the intercalation compound of 2-ABM and Na-TSM. Interestingly, a difference in the formation behavior of intercalation compunds between 4-ABE and 2-ABM was observed. The intercalation compound of Na-TSM and 4-ABE or 2-ABM showed efficient UV absorption in the UV_B and UV_A wavelength regions. Therefore, application of a layered compound of Na-TSM and 4-ABE or 2-ABM as a novel UV screening system is promising.

• 公益社団法人日本薬学会の論文
• 1997-12-15

著者

• Matsumoto M

  Osaka Medical Center For Cancer And Cardiovascular Diseases Osaka

• Matsumoto Misako

  Department Of Immunology Osaka Medical Center For Cancer And Cardiovascular Diseases

• Kimura Chisato

  Department of Applied Chemistry, Chuo University

• Watanabe Yoshiteru

  Department of Pharmaceutics and Biopharmaceutics, Showa Pharmaceutical University

• Kimura Chisato

  Departments Of Pharmaceutics Showa College Of Phamaceutical Sciences

• Matsumoto Mitsuo

  Department of Pharmaceutics, Showa Pharmaceutical University

• Matsumoto Mitsuharu

  Takeda Chemical Industries Ltd. Pharmaceutical Research Division

• UTOGUCHI Naoki

  Department of Pharmaceutics and Biopharmaceutics, Showa Pharmaceutical University

• Watanabe Yoshiteru

  Department Of Pharmaceutics And Biopharmaceutics Showa Pharmaceutical University

• Watanabe Y

  Showa Pharmaceutical Univ.

• Matsumoto Mitsuo

  Department Of Pharmaceutics Showa Pharmaceutical University

• Watanabe Yoshiteru

  Showa Pharmaceutical Univ.

• KOIZUMI KEI-ICHI

  Department of Pharmaceutics, Showa College of Pharmaceutical Sciences

• Kanzaki Yasushi

  Analytical Chemistry Showa College Of Pharmaceutical Sciences

• Kimura Chisato

  Department Of Applied Chemistry Chuo University

• TAI Yukiko

  Departments of Pharmaceutics Showa College of Phamaceutical Sciences

• YAMADA Noriyo

  Departments of Pharmaceutics Showa College of Phamaceutical Sciences

• Utoguchi Naoki

  Department Of Biopharmaceutics School Of Pharmaceutical Sciences Teikyo University

• Koizumi K

  Departments Of Pharmaceutics Showa College Of Phamaceutical Sciences

• Yamada N

  Kitasato Univ. Aomori Jpn

• Matsumoto Mitsuhiro

  First Department Of Internal Medicine Kumamoto University School Of Medicine

• Matsumoto Mitsuo

  Department Of Pharmaceutics And Biopharmaceutics Showa Pharmaceutical University

• Matsumoto Mitsuo

  Department Of Ophthalmology Hirosaki University School Of Medicine

• Matsumoto Mitsuo

  Department of Hydrocarbon Chemistry, Faculty of Engineering, Kyoto University

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