A Novel Strategy for a Drug Delivery System Using a Claudin Modulator
スポンサーリンク
概要
- 論文の詳細を見る
With the continued progress in genomic drug discovery, the high-throughput production of drug candidates has become possible, and thus today there are a number of candidates that are extremely effective both in cellfree and in cell models. However, a drug delivery system suitable for the high-throughput production has yet to be fully developed. In tissues, the tight junction (TJ) plays a pivotal role as both a barrier to restrict various substances and in intra-tissue maintenance. Claudin, a ca. 23kDa transmembrane protein with four transmembrane domains, is responsible for the TJ functions. Interestingly, for each of the 24 members of the claudin family, expression profiles and exact barrier functions differ. Therefore, claudin may be a potential target for use as a drug delivery system via a paracellular route. The C-terminal fragment of Clostridium perfringens enterotoxin (C-CPE) is known to modulate the barrier function of claudin. We found that C-CPE is a potent absorption-enhancer and that this enhancing activity is 400-fold greater than clinically used enhancers. The enhancing activity examined in this study involved an interaction between C-CPE and claudin-4. These findings indicate that claudin might be a novel target for a drug delivery system. In the current review, we describe about background and data on our research about claudin modulator, and we also discuss the possibility of the use of the claudin family in a new approach for developing a drug delivery system.
- 公益社団法人日本薬学会の論文
- 2006-09-01
著者
-
近藤 昌夫
Graduate School Of Pharmaceutical Sciences Osaka University:department Of Pharmaceutics And Biopharm
-
近藤 昌夫
Graduate School Of Pharmaceutical Sciences Osaka Univ.
-
Yagi Kiyohito
Department Of Biochemical Engineering Faculty Of Pharmaceutical Sciences Osaka University
-
Fujii Makiko
Department of Pharmaceutics and Biopharmaceutics, Showa Pharmaceutical University
-
Watanabe Yoshiteru
Department of Pharmaceutics and Biopharmaceutics, Showa Pharmaceutical University
-
Fujii Makiko
Showa Pharmaceutical Univ.
-
Fujii Makiko
Department Of Chemistry Faculty Of Engineering Gifu University
-
KONDOH Masuo
Department of Biopharmaceutics and Pharmaceutics, Showa Pharmaceutical University
-
Yagi Kiyohito
Department Of Bio-functional Molecular Chemistry Graduate School Of Pharmaceutical Sciences Osaka Un
-
Kawase M
Research And Development Center Kobayashi Pharmaceutical Co. Ltd.
-
Fujii M
Department Of Pharmaceutics And Biopharmaceutics Showa Pharmaceutical University
-
Kawase Masaya
Faculty Of Education Kagawa University
-
TAKAHASHI Azusa
Department of Pharmaceutics and Biopharmaceutics, Showa Pharmaceutical University
-
Watanabe Yoshiteru
Department Of Pharmaceutics And Biopharmaceutics Showa Pharmaceutical University
-
Watanabe Y
Showa Pharmaceutical Univ.
-
Fujii M
Showa Univ. Tokyo Jpn
-
Watanabe Yoshiteru
Showa Pharmaceutical Univ.
-
Takahashi Azusa
Department Of Pharmaceutics And Biopharmaceutics Showa Pharmaceutical University
関連論文
- Effects of Application Method on Skin Penetration of Carboxyfluorescein Incorporated in Liposomes
- Involvement of Oxidative Stress in the Synthesis of Metallothionein Induced by Mitochondrial Inhibitors(Pharmacology)
- Sulfating-Activity and Stability of cDNA-Expressed Allozymes of Human Phenol Sulfotransferase, ST1A31 (^Arg) and ST1A32 (^His), Both of Which Exist in Japanese as Well as Caucasians^1
- Morphological regulation and aggregate formation of rabbit chondrocytes on dendrimer-immobilized surfaces with D-glucose display(CELL AND TISSUE ENGINEERING)
- Effect of Particle Size of Drug on Conversion of Crystals to an Amorphous State in a Solid Dispersion with Crospovidone
- Glucose Transporter Mediation Responsible for Morphological Changes of Human Epithelial Cells on Glucose-Displayed Surfaces(CELL AND TISSUE ENGINEERING)
- Synergistic Effect of D-Glucose and Epidermal Growth Factor Display on Dynamic Behaviors of Human Epithelial Cells(CELL AND TISSUE ENGINEERING)
- Response of Human Epithelial Cells to Culture Surfaces with Varied Roughnesses Prepared by Immobilizing Dendrimers with/without D-Glucose Display(CELL AND TISSUE ENGINEERING)
- Availability of Bone Marrow Stromal Cells in Three-Dimensional Coculture with Hepatocytes and Transplantation into Liver-Damaged Mice(MEDICAL BIOTECHNOLOGY, Advances in Biomedical Science and Engineering)
- Maintenance of Hepatocyte Functions by Coculture with Bone Marrow Stromal Cells (MEDICAL BIOTECHNOLOGY)
- Dendrimer-Immobilized Culture Surface as a Tool to Evaluate Formation of Cellular Cytoskeleton of Anchorage-Dependent Cells (BIOCHEMICAL ENGINEERING)
- タイトジャンクション構成蛋白質Claudinを利用した新規薬物送達方法の構築
- Hepatoprotective Effect of Vitamin B_ on Dimethylnitrosamine-Induced Liver Injury(Pharmacology)
- Protection against D-Galactosamine-Induced Acute Liver Injury by Oral Administration of Extracts from Lentinus edodes Mycelia(Pharmacology)
- Suppression of Cell Death in Primary Rat Hepatocytes by α_1-Acid Glycoprotein(Cell and Tissue Engineering)
- Novel Function of Rare Catechin, Epigallocatechin-3-(3"-O-methyl)gallate, against Cold Injury in Primary Rat Hepatocytes(MISCELLANEOUS)
- Transplantation of Hepatocytes Cultured on Hydroxyapatite into Nagase Analbuminemia Rats (MEDICAL BIOTECHNOLOGY)
- Enhancing Effect of Zinc on Hepatoprotectivity of Epigallocatechin Gallate in Isolated Rat Hepatocytes
- Antioxidative Activity of (-)-Epigallocatechin-3-(3"-O-methyl) gallate Isolated from Fresh Tea Leaf and Preliminary Results on Its Biological Activity
- Effectiveness of Polyamidoamine Dendrimers Modified with Tripeptide Growth Factor, Glycyl-L-Histidyl-L-Lysine, for Enhancement of Function of Hepatoma Cells
- Immobilization of Tripeptide Growth Factor Glycyl-L-histidyl-L-lysine on Poly(vinylalcohol)-quarternized Stilbazole (PVA-SbQ) and Its Use as a Ligand for Hepatocyte Attachment
- Cytostatic effect of phenobarbital on a human hepatoma cell line
- Note of assay of hepatic P-450 activity for evaluation of the function of bioartificial liver support system
- Oxidation of 2-Methoxyphenol by Synthetic Copper-ferrite
- Effectiveness of Fructose-Modified Chitosan as a Scaffold for Hepatocyte Attachment
- Effect of zinc on hepatoprotectivity of α1-acid glycoprotein
- Hepatoprotective Effect of Extracts from Lentinus edodes Mycelia on Dimethylnitrosamine-Induced Liver Injury(Pharmacology)
- Liver Protection by Bis (Maltolato) Zinc(II) Complex
- Correlation between the Physicochemical Property of Some Nonsteroidal Anti-inflammatory Drugs and Changes in Adenosine Triphosphate, Glutathione and Hemoglobin in Rat Erythrocytes(Biopharmacy)
- Evaluation of Pharmacokinetic parameters of Cibenzoline after Administration of a Single Oral Dose in Healthy Volunteers
- Evaluation of Pharmacokinetic Parameters of Cibenzoline after Administration of a Single Oral Dose in Healthy Volunteers
- Determination of concentrations of flecainide in human serum by high-performance liquid chromatography on a fluorocarbon-bonded silica gel column
- In Vivo Cloning of a Pseudomonas oxalaticus σ^-Like Gene Acting in Expression of Hydrogenase Genes From Alcaligenes hydrogenophilus
- Alcaligenes hydrogenophilus Lithoautotrophy Mutants Defective in Hydrogenase(s) Encoded on Plasmid and σ^-Like Factor Encoded on Chromosome
- In Vivo Cloning of Genes Determining Lithoautotrophy(Aut)on a Plasmid from Alcaligenes hydrogenophilus
- Protective Effect of Montmorillonite on Plasmid DNA in Oral Gene Delivery into Small Intestine(Miscellaneous)
- Polyethyleneimine/Chitosan Hexamer-Mediated Gene Transfection into Intestinal Epithelial Cell Cultured in Serum-Containing Medium(MEDICAL BIOTECHNOLOGY)
- 4'-Hydroxylation of Flurbiprofen by Rat Liver Microsomes in Fasting and Feeding Conditions(Biopharmacy)
- Effects of Aspirin and/or Salicylate on Hydrolysis and Glucuronidation of Indomethacin in Rat Erythrocytes and Hepatocytes
- Mechanism of Enhancement Effect of Dendrimer on Transdermal Drug Permeation through Polyhydroxyalkanoate Matrix(MISCELLANEOUS)
- Novel Transdermal Drug Delivery System with Polyhydroxyalkanoate and Starburst Polyamidoamine Dendrimer
- Terahertz Absorption Spectra of Original and Generic Ceftazidime
- Requirement of Oxygen for Dark Hydrogen Evolution by a Green Alga, Chlamydomonas reinhardtii
- Pharmacokinetics of Acetaminophen from Rapidly Disintegrating Compressed Tablet Prepared Using Microcrystalline Cellulose(PH-M-06)and Spherical Sugar Granules
- Preparation of Rapidly Disintegrating Tablet Using New Types of Microcrystalline Cellulose(PH-M Series)and Low Substituted-Hydroxypropylcellulose or Spherical Sugar Granules by Direct Compression Method
- Preparation of Griseofulvin for Topical Application Using N-Methyl-2-pyrrolidone
- Growth Inhibition of Human Leukemia HL-60 Cells by an Antisense Phosphodiester Oligonucleotide Encapsulated into Fusogenic Liposomes
- Transmissibility of Hydrogen Oxidation (Hox) Plasmid from Alcaligenes hydrogenophilus
- Application of Glutaraldehyde-Crosslinked Chitosan as a Scaffold for Hepatocyte Attachment
- In Vitro Maintenance of Liver Function in Hierarchical Co-Culture of Hepatocytes and Non-Parenchymal Liver Cells
- Effect of Polyaniline-coated Surface on the Formation of Multicellular Spheroids of Hepatocytes
- In Vivo Recombination of Two R68.45-Primes, One Carrying Plasmid Genes for Autotrophy (Aut) from Alcaligenes hydrogenophilus and the Other Carrying a σ^-Like Chromosome Gene from Pseudomonas oxalaticus
- Study on the Discrepancy in Responses Given by Patients to Questions Regarding Subjective Symptoms
- Study on Factors that Contribute to Poor Patient Compliance with Medication in Japan
- New ent-Kaurene-Type Diterpenoids Possessing Cytotoxicity from the New Zealand Liverwort Jungermannia Species
- A Novel Strategy for a Drug Delivery System Using a Claudin Modulator
- Efficient Gene Transfer into Differentiated Human Trophoblast Cells with Adenovirus Vector Containing RGD Motif in the Fiber Protein(Biopharmacy)
- Evaluation of the Compaction Properties of a Solid Dispersion of Indomethacin with Crospovidone by Tableting Process Analyzer
- Efficient Gene Transfer into Human Trophoblast Cells with Adenovirus Vector Containing Chimeric Type 5 and 35 Fiber Protein(Biopharmacy)
- A Novel Method for Predicting Disintegration Time in the Mouth of Rapidly Disintegrating Tablet by Compaction Analysis Using TabAll(Communication to the Editor)
- Cytotoxic and Apoptosis-Inducing ent-Kaurane-Type Diterpenoids from the Japanese Liverwort Jungermannia truncata NEES
- Preparation and Evaluation of Tablets Rapidly Disintegrating in Salive Containing Bitter-Taste-Masked Granules by the Compression Method
- Effect of Tranilast Oily Gel on Carrageenin-Induced Granulation in Rats
- Effect of UV-Absorbing Agents on Photodegradation of Tranilast in Oily Gels
- In Vitro Release of Tranilast from Oily Gels and Penetration of the Drug into Yucatan Micropig Skin
- Screening of Bacteriophages Producing Endo-N-Acetylneuraminidase
- A New Compression Tableting Method Using a Punch Coated with Amorphous Alloys
- ACUTE AND SUBCHRONIC EFFECTS OF BOMETOLOL ON BLOOD PRESSURE IN HYPERTENSIVE RATS
- Molecular Cloning and Characterization of a Novel Bacteriophage-Associated Sialidase
- Activation of Caspase-3 in HL-60 Cells Treated with Pyrithione and Zinc(Toxicology)
- Classical Conditioning of Metallothionein Synthesis in Mice
- Activation of a 36-kDa Myelin Basic Protein Kinase during Cadmium-Induced Apoptosis in Human Leukemia HL-60 Cells
- Cytochrome C Release from Mitochondria Induced by Cadmium
- Cadmium Acetate Mediated Conversion of Selenothioic Acid S-Alkyl Esters to Selenophenes and Ketene Selenothioacetals
- Pharmacodynamic Activity (Leukopoietic Effect) of Recombinant Human Granulocyte Colony-Stimulating Factor (rhG-CSF) after Rectal Administration in Rabbits with Leukopenia Induced by Cyclophosphamide
- Note in Statistical Treatment of Medical and Pharmaceutical Data(METHODS, Advances in Biomedical Science and Engineering)
- Application of Partial Least Square on Quantitative Analysis of L-, D-, and DL-Tartaric Acid by Terahertz Absorption Spectra
- Magnetic Phase Diagram of Dy Determined by AC Calorimetry
- Preparation and Evaluation of Heat-sensitive Melting Gel : Acetaminophen Gel
- The Effect of Dried Aluminum Hydroxide Gel on the Blood Concentration of Cyclosporine-A
- Consolidation and Drug Release Characteristics of Macrogol-Matrix Tablets Containing Nifedipine and Increased Bioavailability of Nifedipine from These Tablets in Rabbits
- Pharmacodynamics and Pharmacokinetics of Recombinant Human Granulocyte Colony-Stimulating Factor (rhG-CSF) after Administration of a Rectal Dosage Vehicle
- A New Ultraviolet Protective Agent of the Intercalation Compound of Aminobenzoic Acid Esters (UV Absorber) and Synthetic Mica (Inorganic Layered Compound)
- Duration of Absorption-Enhancing Effect of Sodium Octanoate, Sodium Hexanoate or Glyceryl-1-monooctanoate on Rectal Absorption of Gentamicin in Rabbits
- Hepatoprotective Effect of Syringic Acid and Vanillic Acid on CCl4-Induced Liver Injury
- Two Step Conversion of Selenothioacetic Acid S-Butyl Ester to 1, 3-Oxaselenolanes via Regio- and Stereoselective Ring Opening of Oxiranes
- PHARMACEUTICAL EVALUATION OF HOLLOW TYPE SUPPOSITORIES. V. PREPARATION OF VALPROIC ACID SUPPOSITORY AND RECTAL ABSORPTION OF VALPROIC ACID IN RABBITS
- PHARMACEUTICAL EVALUATION OF HOLLOW TYPE SUPPOSITORIES. IV. IMPROVEMENT OF BIOAVAILABILITY OF PROPRANOLOL IN RABBITS AFTER RECTAL ADMINISTRATION
- PHARMACEUTICAL EVALUATION OF HOLLOW TYPE SUPPOSITORY
- Pharmacokinetics and Pharmacodynamics of Human Chorionic Gonadotropin (hCG) after Rectal Administration of Hollow-Type Suppositories Containing hCG
- Effect of Chemical Modification of Tyrosine Residues on Activities of Bacterial Lipase
- Improvement of Heat Stability of Yeast Lipase by Chemical Modification with a Heterobifunctional Photogenerated Reagent
- Application of Terahertz Absorption Spectroscopy to Evaluation of Aging Variation of Medicine
- Studies of Drug Delivery Systems for a Therapeutic Agent Used in Osteoporosis. II. Enhanced Absorption of Elcatonin from Nasal Mucosa in Rabbits
- Hepatoprotective Effect of Syringic Acid and Vanillic Acid on Concanavalin A-Induced Liver Injury
- Recent Studies on Metallothionein : Protection Against Toxicity of Heavy Metals and Oxygen Free Radicals
- Effects of Non-covalent Interaction of Dimethyl Suberimidate on Lipase Stability(Biological Chemistry)
- Influence of Admixture with Urea Ointment and White Petrolatum on the Penetration of Corticosteroids into Yucatan Micropig Skin
- Regeneration of NADPH by Frozen-thawed Cells of a Blue-green Alga, Synechococcus sp.
- Percolation Analysis in Electrical Conductivity of Madin-Darby Canine Kidney and Caco-2 Cells by Permeation-Enhancing Agents