Suppression of Cell Death in Primary Rat Hepatocytes by α_1-Acid Glycoprotein(Cell and Tissue Engineering)
スポンサーリンク
概要
- 論文の詳細を見る
In screening for effective additives for the long-term culture of hepatocytes, the hepatoprotective effect of α_1-acid glycoprotein (AGP) was observed. AGP prevented primary hepatocytes from undergoing cell death induced by the chemical toxin, bromobenzene. Moreover, AGP added to medium was found to maintain the number of viable hepatocytes for as long as 6 d. The hepatoprotective effect of AGP was lost by removing sialic acid groups at the N-glycan chain terminal of AGP. It is shown that the complete form of N-glycan chain is needed for the hepatoprotectivity of AGP.
- 社団法人日本生物工学会の論文
- 2005-01-25
著者
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近藤 昌夫
Graduate School Of Pharmaceutical Sciences Osaka University:department Of Pharmaceutics And Biopharm
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Kawase Masaya
Graduate School Of Pharmaceutical Sciences Osaka Univ.
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近藤 昌夫
Graduate School Of Pharmaceutical Sciences Osaka Univ.
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Yagi Kiyohito
Graduate School of Pharmaceutical Sciences, Osaka University
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Yagi K
Graduate School Of Pharmaceutical Sciences Osaka University
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Yagi Kiyohito
Graduate School Of Pharmaceutical Sciences Osaka Univ.
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Yagi K
Osaka Univ. Osaka Jpn
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Kawase M
Nagahama Institute Of Bio-science And Technology
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Kawase M
Osaka Univ. Osaka Jpn
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Isoda Katsuhiro
Graduate School of Pharmaceutical Sciences, Osaka University
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KAGAYA Noritaka
Graduate School of Pharmaceutical Sciences, Osaka University
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AKAMATSU Soichiro
Graduate School of Pharmaceutical Sciences, Osaka University
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KAMIYOSHI AKIKO
Division of Laboratory Animal Research, Research Center for Human and Environmental Sciences, Shinsh
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TAGAWA YOH-ICHI
Division of Laboratory Animal Research, Research Center for Human and Environmental Sciences, Shinsh
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AKAMATSU Soh-ichiro
Graduate School of Pharmaceutical Sciences, Osaka University
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Kagaya Noritaka
Graduate School Of Pharmaceutical Sciences Osaka University
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Yagi Kiyohito
Department Of Biocehmical Engineering Faculty Of Pharmaceutical Sciences Osaka University
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Kamiyoshi Akiko
Department Of Organ Regeneration Shinshu University Graduate School Of Medicine
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Akamatsu Soichiro
Graduate School Of Pharmaceutical Sciences Osaka University
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Kawase M
Research And Development Center Kobayashi Pharmaceutical Co. Ltd.
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Kawase Masaya
Faculty Of Education Kagawa University
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Kamiyoshi Akiko
Department Of Organ Regeneration Shinshu University School Of Medicine
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