Adrenomedullin in sinusoidal endothelial cells play protective roles against cold injury of liver
スポンサーリンク
概要
- 論文の詳細を見る
Donor organ damage caused by cold preservation is a major problem affecting liver transplantation. Cold preservation most easily damages liver sinusoidal endothelial cells (LSECs), and information about the molecules modulating LSECs function can provide the basis for new therapeutic strategies. Adrenomedullin (AM) is a peptide known to possess anti-apoptotic and anti-inflammatory properties. AM is abundant in vascular endothelial cells, but levels are comparatively low in liver, and little is known about its function there. In this study, we demonstrated both AM and its receptors are expressed in LSECs. AM treatment reduced LSECs loss and apoptosis under cold treatment. AM also downregulated cold-induced expression of TNF alpha, IL1 beta, IL6, ICAM1 and VCAM1. AM reduced apoptosis and expression of ICAM1 and VCAM1 in an in vivo liver model subjected to cold storage. Conversely, apoptosis was exacerbated in livers from AM and RAMP2 (AM receptor activity-modifying protein) knockout mice. These results suggest that AM expressed in LSECs exerts a protective effect against cold-organ damage through modulation of apoptosis and inflammation.
著者
-
Kamiyoshi Akiko
Department Of Organ Regeneration Shinshu University Graduate School Of Medicine
-
Kamiyoshi Akiko
Department Of Organ Regeneration Shinshu University School Of Medicine
関連論文
- Adrenomedullin in sinusoidal endothelial cells play protective roles against cold injury of liver
- Suppression of Cell Death in Primary Rat Hepatocytes by α_1-Acid Glycoprotein(Cell and Tissue Engineering)
- Novel Function of Rare Catechin, Epigallocatechin-3-(3"-O-methyl)gallate, against Cold Injury in Primary Rat Hepatocytes(MISCELLANEOUS)
- Effect of zinc on hepatoprotectivity of α1-acid glycoprotein
- Liver Protection by Bis (Maltolato) Zinc(II) Complex
- Liver Organogenesis from Murine Embryonic Stem Cells(International Symposium of Maxillofacial and Oral Regenerative Biology in Okayama 2005)
- PJ-337 RAMP2, a Novel Regulator of Angiogenesis, Vascular Integrity, and Homeostasis(PJ057,Translational Science (Cardiac) (H),Poster Session (Japanese),The 73rd Annual Scientific Meeting of The Japanese Circulation Society)
- OE-209 Adrenomedullin-RAMP2 System is Essential for Angiogenesis and Vascular Stability(Genetics/Genetically engineered models/Gene therapy-1(H/M), The 71st Annual Scientific Meeting of the Japanese Circulation Society)
- PE-297 Roles of Adrenomedullin-RAMP2 System in Angiogenesis and Vascular Stability(Regeneration (angionenesis/myocardial regeneration)-5 (M) PE50,Poster Session (English),The 70th Anniversary Annual Scientific Meeting of the Japanese Circulation Society)