Liver Protection by Bis (Maltolato) Zinc(II) Complex
スポンサーリンク
概要
- 論文の詳細を見る
The aim of this study was to perform screening of a novel drug for treating liver injury. Bis(maltolato)zinc(II) complex [Zn(Mal)2], which was previously reported to possess insulinomimetic activity, was found to have potency against experimentally induced liver injury both in vitro and in vivo. Cultured rat hepatocytes were treated with bromobenzene for 24 h to induce cellular injury. Zn(Mal)2 of various concentrations was added along with bromobenzene in order to evaluate the hepatoprotective activity of Zn(Mal)2 in vitro. The number of viable hepatocytes decreased by 42% in the culture with bromobenzene. However, hepatocyte viability was maintained when Zn(Mal)2 was added to the bromobenzene culture. The hepatoprotective activity of Zn(Mal)2 in vivo was investigated using a concanavalin A-induced liver injury model in BALB/c mice. Changes in serum aminotransferase activities and the secretion of several cytokines were measured. The hepatoprotective effect of Zn(Mal)2 was also demonstrated in vivo by the suppression of serum aspartate aminotransferase and alanine aminotransferase elevation. No significant changes in serum cytokines associated with the induction of hepatic damage were observed in the concanavalin A-induced injury model. However, examination of concanavalin A-treated mouse splenocytes revealed a dose-dependent suppression of cytokine secretions by Zn(Mal)2. Zn(Mal)2 possessed hepatoprotective activity and might exert its effect by a number of mechanisms.
- 社団法人 日本実験動物学会の論文
- 2004-01-01
著者
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近藤 昌夫
Graduate School Of Pharmaceutical Sciences Osaka University:department Of Pharmaceutics And Biopharm
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Kawase Masaya
Graduate School Of Pharmaceutical Sciences Osaka Univ.
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近藤 昌夫
Graduate School Of Pharmaceutical Sciences Osaka Univ.
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Yagi Kiyohito
Graduate School of Pharmaceutical Sciences, Osaka University
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Yagi K
Graduate School Of Pharmaceutical Sciences Osaka University
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Yagi Kiyohito
Graduate School Of Pharmaceutical Sciences Osaka Univ.
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Yagi K
Osaka Univ. Osaka Jpn
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Kawase M
Osaka Univ. Osaka Jpn
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KAGAYA Noritaka
Graduate School of Pharmaceutical Sciences, Osaka University
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KAMIYOSHI AKIKO
Division of Laboratory Animal Research, Research Center for Human and Environmental Sciences, Shinsh
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TAGAWA YOH-ICHI
Division of Laboratory Animal Research, Research Center for Human and Environmental Sciences, Shinsh
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AKAMATSU Soh-ichiro
Graduate School of Pharmaceutical Sciences, Osaka University
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MUTO Shin-ichi
Toxicology Research Laboratory, R&D, Kissei Pharmaceutical Co. Ltd.
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Kagaya Noritaka
Graduate School Of Pharmaceutical Sciences Osaka University
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Yagi Kiyohito
Department Of Biocehmical Engineering Faculty Of Pharmaceutical Sciences Osaka University
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Kamiyoshi Akiko
Department Of Organ Regeneration Shinshu University Graduate School Of Medicine
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Akamatsu Soichiro
Graduate School Of Pharmaceutical Sciences Osaka University
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Muto Shin-ichi
Toxicology Research Laboratory R&d Kissei Pharmaceutical Co. Ltd.
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Kawase Mitsuo
Ngk Insulators Ltd.
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Kawase M
Research And Development Center Kobayashi Pharmaceutical Co. Ltd.
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Kawase Masaya
Faculty Of Education Kagawa University
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Kamiyoshi Akiko
Department Of Organ Regeneration Shinshu University School Of Medicine
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