EFFECTS OF METHYL (+) (3S)-1,2,3,4-TETRAHYDRO-3-HYDROXY-METHYL-β-CARBOLINE-2-CARBODITHIOATE (THC), A NEW HEPATOPROTECTIVE AGENT, ON PROTEIN SYNTHESIS AND CHRONIC LIVER INJURY INDUCED BY CARBON TETRACHRORIDE IN RATS
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概要
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The effects of oral administration of methyl (+) (3S)-1,2,3,4-tetrahydro-3-hydroxymethyl-β-carboline-2-carbodithioate (THC) on protein synthesis in the liver and chronic liver injury induced by carbon tetrachloride (CCl_4) in rats were studied. THC increased liver weight and the contents of protein and ribonucleic acid, but not deoxyribonucleic acid, in the liver. THC also accelerated the ^<14>C-leucine incorporation into hepatic microsomal and cytosol proteins in rats when the animals were treated with THC 24 h before sacrifice. In addition, when the animals were treated with THC during the latter half of a 5 weeks CCl_4-treatment period, THC had a marked therapeutic effect on CCl_4-induced chronic liver injury in rats by an improvement of the decreased body weight gain, suppression of the elevated serum enzyme activities (glutamic pyruvic transaminase, glutamic oxaloacetic transaminase and alkaline phosphatase) and increases in the decreased serum total protein and glucose contents. In the liver, THC also improved the decreased protein content, the increased triglyceride content and histopathological changes. These results suggested that THC stimulates protein synthesis in the liver and has a therapeutic effect on chronic liver injury induced by CCl_4.
- 公益社団法人日本薬学会の論文
著者
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Matsumoto M
Osaka Medical Center For Cancer And Cardiovascular Diseases Osaka
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Matsumoto Misako
Department Of Immunology Osaka Medical Center For Cancer And Cardiovascular Diseases
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KITAMURA Kazuyuki
Safety Research Laboratory, Research Division, Mitsubishi Tanabe Pharma Corporation
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Kitamura Kazuyuki
Safety Res. Lab. Mitsubishi Tanabe Pharma Corp.
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Iwasaki H
Tanabe Seiyaku Co. Ltd. Toda Jpn
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Matsumoto Mitsuharu
Takeda Chemical Industries Ltd. Pharmaceutical Research Division
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Matsuoka Y
Safety Research Laboratory And Organic Chemistry Research Laboratory Tanabe Seiyaku Co. Ltd.
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SAIGA Yutaka
Lead Optimization Research Laboratory, Tanabe Seiyaku Co., Ltd.,
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IIJIMA Ikuo
Lead Optimization Research Laboratory, Tanabe Seiyaku Co., Ltd.,
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Iijima I
Lead Optimization Research Laboratory Tanabe Seiyaku Co. Ltd.
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Saiga Y
Lead Optimization Research Laboratory Tanabe Seiyaku Co. Ltd.
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MATSUMOTO MAMORU
Safety Research Laboratory
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MATSUOKA YUZO
Safety Research Laboratory
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SAIGA YUTAKA
Safety Research Laboratory
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IIJIMA IKUO
Safety Research Laboratory
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IWASAKI HITOSHI
Safety Research Laboratory
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MORITA TAKASHI
Safety Research Laboratory
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Morita T
Univ. Shizuoka Shizuoka‐shi Jpn
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Kitamura Kazuyuki
Safety Research Laboratory:organic Chemistry Research Laboratory:biological Research Laboratory:tana
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