Time-course changes of hematology and clinical chemistry values in pregnant rats
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概要
- 論文の詳細を見る
The aim of this study is to report how pregnancy alters hematology and clinical chemistry values in rats. Female and male Sprague-Dawley rats were mated; the day of copulation was designated as Day 0. Hematology and clinical chemistry measurements were conducted on Days 7, 14, 17 and 21 in pregnant rats. Measurements were also conducted in non-pregnant rats. Red blood cells (RBC), hemoglobin (Hb), hematocrit (Ht), total protein and albumin decreased on Days 7, 14, 17 and 21; sodium, chloride and glucose decreased on Days 14, 17 and 21; iron decreased on Days 17 and 21; hemoglobin content of reticulocytes (CHr), calcium, inorganic phosphorus and the albumin/globulin ratio decreased on Day 21 ; and total cholesterol, phospholipid and high-density lipoprotein cholesterol decreased on Day 14 in pregnant rats compared with non-pregnant rats. Reticulocyte increased on Days 7, 14 and 17; mean corpuscular hemoglobin, mean corpuscular hemoglobin concentration, neutrophil count and rate increased on Days 14, 17 and 21; platelets, fibrinogen, triglyceride and free fatty acid increased on Days 17 and 21; and activated partial thromboplastin time was prolonged on Days 17 and 21 in pregnant rats compared with non-pregnant rats. The decreased RBC, Hb, Ht, CHr and iron in pregnant rats indicated that they suffered from iron deficiency anemia. These data can be used as background information for effective evaluation in reproductive toxicology studies.
- 日本トキシコロジー学会の論文
- 2008-08-01
著者
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NISHIDA Atsuyuki
Safety Research Laboratory, Research Division, Mitsubishi Tanabe Pharma Corporation
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KITAMURA Kazuyuki
Safety Research Laboratory, Research Division, Mitsubishi Tanabe Pharma Corporation
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Nishida Atsuyuki
Safety Res. Lab. Res. Div. Mitsubishi Tanabe Pharma Corp.
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Nishida Atsuyuki
Drug Safety Research Laboratories Tanabe Seiyaku Co. Ltd.
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Honda Tatsuya
Safety Research Laboratory, Mitsubishi Tanabe Pharma Corporation
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Honda Katsuya
Safety Research Laboratory, Mitsubishi Tanabe Pharma Corporation
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Kokubun Chisato
Safety Research Laboratory, Mitsubishi Tanabe Pharma Corporation
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Nishimura Tomonari
Safety Research Laboratory, Mitsubishi Tanabe Pharma Corporation
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Hasegawa Mina
Safety Research Laboratory, Mitsubishi Tanabe Pharma Corporation
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Inui Toshihide
Research Coordination & Administration Department, Mitsubishi Tanabe Pharma Corporation
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Honda Katsuya
Safety Research Laboratory Mitsubishi Tanabe Pharma Corporation
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Kitamura Kazuyuki
Safety Res. Lab. Mitsubishi Tanabe Pharma Corp.
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Kitamura Kazuyuki
Safety Res. Lab. Res. Div. Mitsubishi Tanabe Pharma Corp.
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Honda Tatsuya
Safety Research Laboratory Mitsubishi Tanabe Pharma Corporation
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Hasegawa Mina
Safety Res. Lab. Res. Div. Mitsubishi Tanabe Pharma Corp.
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Nishimura T
Safety Research Laboratory Mitsubishi Tanabe Pharma Corporation
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Kokubun Chisato
Safety Research Laboratory Mitsubishi Tanabe Pharma Corporation
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