A Norbergenin Derivative Inhibits Neuronal Cell Damage Induced by Tunicamycin(Molecular and Cell Biology)

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概要

• 論文の詳細を見る

• Several chemically synthesized compounds were examined for protective effects against the cell damage in tunicamycin-treated human neuroblastoma IMR-32 cells. Among the compounds tested, an antioxidant, Norbergenin-11-caproate (10μM), exhibited complete protection against the cell growth inhibitory effect of tunicamycin but did not inhibit the induction of Bip/GRP78 mRNA by tunicamycin. Both norbergenin-11-caproate and α-tocopherol completely inhibited the production of reactive oxygen species induced by tunicamycin, however, α-tocopherol inhibited tunicamycin-induced cell damage only partially, even at 100μM. These findings suggest the potential of Norbergenin-11-caproate for therapeutic application in endoplasmic reticulum (ER) stress-dependent diseases implicating a specific mechanism other than anti-oxidative one.

• 社団法人日本薬学会の論文
• 2006-07-01

著者

• Sato Masao

  Faculty of Pharmaceutical Science, Tokushima Bunri University

• FUKUYAMA Yoshiyasu

  Faculty of Pharmaceutical Sciences, Tokushima Bunri University

• Sato Masao

  徳島文理大学 薬学部

• TAKAHASHI Hironobu

  Faculty of Pharmaceutical Sciences, Tokushima Bunri University

• Suzuki Shinya

  徳島文理大学 薬学部

• TAKIGUCHI Masufumi

  Faculty of Pharmaceutical Sciences, Tokushima Bunri University

• SUZUKI Shinya

  Faculty of Pharmaceutical Sciences, Tokushima Bunri University

• OKUSE Yui

  Faculty of Pharmaceutical Sciences, Tokushima Bunri University

• KAWASE Masafumi

  Faculty of Pharmaceutical Sciences, Tokushima Bunri University

• Sono M

  Faculty Of Pharmaceutical Sciences Tokushima Bunri University

• Suzuki Shinya

  Faculty Of Pharmaceutical Sciences Tokushima Bunri University

• Fukuyama Yoshiyasu

  Faculty Of Pharmaceutical Science Tokushima Bunri University

• Okuse Yui

  Faculty Of Pharmaceutical Sciences Tokushima Bunri University

• Takahashi Hironobu

  Faculty Of Pharmaceutical Sciences Tokushima Bunri University

• Kawase Masafumi

  Faculty Of Pharmaceutical Sciences Tokushima Bunri University

• Takiguchi Masufumi

  Faculty Of Pharmaceutical Sciences Tokushima Bunri University:faculty Of Pharmaceutical Sciences Hir

• Sato Masao

  Faculty Of Pharmaceutical Science Tokushima Bunri University

• Takahashi Hironobu

  Facul. Pharmaceut. Sci. Kagawa Camp, Univ. Tokushima Bunri

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