Induction of Metallothionein Synthesis by Cilostazol in Mice and in Human Cultured Neuronal Cell Lines(Molecular and Cell Biology)
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概要
- 論文の詳細を見る
In this study, we examined the effect of Cilostazol to induce metallothionein (MT) in vivo and in vitro. Intraperitoneal injection of Cilostazol increased the expression of both MT-1 and MT-2 mRNA and total MT protein in the mouse liver. Cilostazol also augmented MT-1 mRNA levels in the murine brain. In vitro exposure to Cilostazol significantly augmented intracellular MT protein levels in cultured human brain microvascular endothelial cells (HBMEC) and in the neuroblastoma cell line IMR32. Taken together, these findings suggest that Cilostazol is an inducer of MT in the murine liver and brain, and that it has the potential to directly induce MT in cells. The contribution of the anti-oxidative effect of MT to the anti-stroke effect of Cilostazol was discussed.
- 公益社団法人日本薬学会の論文
- 2007-04-01
著者
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Sato Masao
Faculty of Pharmaceutical Science, Tokushima Bunri University
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SUZUKI Shinya
Faculty of Pharmaceutical Sciences, Tokushima Bunri University
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Nakajima Katsuyuki
Research Institute Of Pharmacological And Therapeutical Development Otsuka Pharmaceutical Co. Ltd.
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Suzuki Shinya
Faculty Of Pharmaceutical Sciences Tokushima Bunri University
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MORI Toyoki
Research Institute of Pharmacological & Therapeutical Development, Otsuka Pharmaceutical Co., Ltd.
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Mori Toyoki
Research Institute Of Pharmacological And Therapeutical Development Otsuka Pharmaceutical Co. Ltd.
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Miyakoda Goro
Research Institute Of Pharmacological And Therapeutical Development Otsuka Pharmaceutical Co. Ltd.
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MASUI Yosuke
Faculty of Pharmaceutical Sciences, Tokushima Bunri University
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OHNUKI Mieko
Faculty of Pharmaceutical Sciences, Tokushima Bunri University
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Masui Yosuke
Faculty Of Pharmaceutical Sciences Tokushima Bunri University
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Ohnuki Mieko
Faculty Of Pharmaceutical Sciences Tokushima Bunri University
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Sato Masao
Faculty Of Pharmaceutical Science Tokushima Bunri University
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