Controlling 3_<10>-Helix and α-Helix of Short Peptides in the Solid State

スポンサーリンク

概要

• 論文の詳細を見る

• L-Leu hexapeptide containing α-aminoisobutyric acid (Aib) forms a right-handed (P) 3_<10>-helix, whereas that containing cyclic α,α-disiibstituted amino acid Ac_5c^<dOM> assumes a right-handed (P) α-helix in the solid state.

• 社団法人日本薬学会の論文
• 2007-05-01

著者

• 田中 正一

  Graduate School Of Pharmaceutical Sciences Kyushu University

• KURIHARA Masaaki

  Division of Organic Chemistry, National Institute of Health Sciences

• NAGANO Masanobu

  Graduate School of Pharmaceutical Sciences, Kyushu University

• DEMIZU Yosuke

  Graduate School of Pharmaceutical Sciences, Kyushu University

• DOI Mitsunobu

  Osaka University of Pharmaceutical Sciences

• TANAKA Masakazu

  Graduate School of Pharmaceutical Sciences, Kyushu University

• SUEMUNE Hiroshi

  Graduate School of Pharmaceutical Sciences, Kyushu University

• MARUYAMA Tokumi

  Faculty of Pharmaceutical Sciences at Kagawa Campus, Tokushima Bunri University

• Tanaka Muneo

  Research Center Shiseido Ltd.

• 出水 庸介

  長崎大学大学院医歯薬学総合研究科

• Tanaka M

  Faculty Of Pharmaceutical Sciences Tokushima Bunri University

• Nagano Masanobu

  Graduate School Of Pharmaceutical Sciences Kyushu University

• 田中 誠

  School Of Pharmaceutical Sciences Kitasato University

• Maruyama Tokumi

  Fac. Of Pharmaceutical Sciences At Kagawa Campus Tokushima Bunri Univ.

• Maruyama Tokumi

  Faculty Of Pharmaceutical Sciences At Kagawa Campus Tokushima Bunri University

• Demizu Yosuke

  Graduate School Of Pharmaceutical Sciences Kyushu University

• Demizu Yosuke

  Faculty Of Pharmaceutical Sciences At Kagawa Campus Tokushima Bunri University

• Suemune H

  Graduate School Of Pharmaceutical Sciences Kyushu University

• Suemune Hiroshi

  Graduate School Of Pharmaceutical Sciences Kyushu University

• Tanaka Masakazu

  Graduate School Of Comprehensive Human Sciences University Of Tsukuba

• Kurihara M

  Division Of Organic Chemistry National Institute Of Health Sciences

• Kurihara Masaaki

  Division Of Organic Chemistry National Institute Of Health Sciences

• Tanaka M

  Nihon Univ. Fujisawa‐shi Jpn

• Demizu Yosuke

  Division Of Organic Chemistry National Institute Of Health Sciences

• Demizu Yosuke

  Division Of Organic Chemistry National Institute Of Health Sciences Ministry Of Health And Welfare

• Tanaka Masami

  Faculty Of Pharmaceutical Sciences Tokushima Bunri University

• Tanaka Masakazu

  Graduate School of Biomedical Sciences, Nagasaki University

• TANAKA Masakazu

  Graduate School of Agriculture, Hokkaido University

関連論文

• Computational Study on Secondary Structure of Oligopeptides Containing α,α-Disubstituted α-Amino Acids
• Controlling 3_-Helix and α-Helix of Short Peptides in the Solid State
• Controlling Helical Secondary Structures by Cyclic α,α-Disubstituted Amino Acids Having Side-Chain Chiral Centers
• Computational Study on Helical Structures of Oligopeptides Containing Chiral Cyclic α,α-Disubstituted α-Amino Acids
• Synthesis of Optically Active Cyclic α,α-Disubstituted Amino Acids by Enzymatic Kinetic Resolution and Conformational Analysis of Their Peptides
• 非タンパク質構成アミノ酸の設計・合成とそのペプチドの2次構造
• Computational Study on Conformation of Oligopeptides Containing Chiral Cyclic α,α-Disubstituted α-Amino Acids
• Synthesis of Various Chiral Cyclic α,α-Disubstituted Amino Acids and Conformational Analysis of Their Peptides
• Chiral Cyclic α,α-Disubstituted α-Amino Acids Bearing Two Chiral Centers and Conformation of Their Peptides
• Computational Study on Conformation of Oligopeptides Controlled by Side Chain Chiralities of α-Amino Acids
• Relationship between α-Amino Acid Chiral Center and Helical Secondary Structure of Its Oligopeptides
• Prediction of Helical Screw Sense of Oligopeptides Containing Chiral Amino Acids : Computational Study
• Controlling the Secondary Structure of Aib Peptides by N-Terminal Proline
• Synthesis of Cyclic α, α-Disubstituted Amino Acids Bearing a γ-Nitrogen Atom
• Controlling the Helical Screw Sense of Oligopeptides by Chiral Cyclic α, α-Disubstituted α-Amino Acid
• Conformation of Oligopeptides Containing Chiral α, α-Disubstituted Amino Acids : Computational Study
• Asymmetric Synthesis and Conformational Analysis of α,α-Disubstituted α-Amino Acids and Their Peptides
• α, α-ジ置換アミノ酸よりなるペプチドのコンフォメーションと分子設計
• Solid-State Conformation of a Hybrid Tripeptide between β-Amino Acid ; 8-Aminocyclooct-4-enecarboxylic Acid and 2-Aminoisobutyric Acid
• Molecular Mechanics Study on Conformational Analysis of Homooligopeptides Prepared from α, α-Disubstituted Amino Acids
• Asymmetric Rh-Catalyzed Intermolecular Hydroacylation of 1,5-Hexadiene with Salicylaldehyde
• Application of Rh-Catalyzed Cyclization to the Formation of a Chiral Quaternary Carbon
• Four Guaianolides from Sinodielsia yannanensis
• Crystal Structures of Acetyl Gramicidin S Analogues
• Structual Analyses for Asymmetric Derivatives of Ascidiacyclamide by X-ray Diffraction and NMR Spectroscopy
• Crystal Structure of Hybrid Dipeptide, (2-Carboxyethyl)-cytosine-1-yl-L-threonine Monohydrate
• Crystal Structure of Hybrid Dipeptide, Cytosinyl-L-tyrosine
• Conformation and Sodium Coordinate Forms of an Endothelin Inhibitor BQ123・Na, Cyclo(-D-Trp-D-Asp^~-Pro-D-Val-Leu-)・Na^+, in the Crystal
• Crystal Structure of 2-[N-(t-Butoxycarbonyl)amino]-4-(thymin-1-yl)-butyric Acid Methyl Ester
• Polymorphism and C-H…O Interaction of Wortmannin, a Phosphatidylinositol 3-Kinase Inhibitor
• Crystal Structure of 3, 4-Dihydroxy-6-fluoro-DL-phenylalanine Monohydrate Used as a Positron Emission Tomography Imaging Ligand
• Fluorophotometric Determination of Hydrogen Peroxide and Other Reactive Oxygen Species with Fluorescein Hydrazide (FH) and Its Crystal Structure
• Absolute Stereostructures of Cell-adhesion Inhibitors, Peribysins A, E, F and G, Produced by a Sea Hare-derived Periconia sp
• Hydrogen Bond between Water and the Phenyl Ring in the Structure of a Dipeptide H-Phe-Leu-NH_2 at 90 K and the Structure-based Energy Estimations
• Interaction Modes between N7-Quarternized Guanine and Cytosine-Containing Dipeptides
• Crystal Structure of Hybrid Dipeptide, Uracil-1-yl-(2-carboxyethyl)-glycine
• Crystal Structure of Cytosine and Alanine Hybrid Dipeptide, Cytosine-1-yl-(2-carboxyethyl)-L-alanine
• Spectroscopic Investigation on the Interaction of NCA0424,a Potent Antitumor Indoloquinoxaline Derivative, with DNA
• Thermodynamic Effect of Commplementary Hydrogen Bond Base Pairing on Aromatic stacking Interaction in the Guanine-X-Trp Complex (X=Adenine, Guanine, Cytosine, Thymine)
• Deletion Mutants of Human Deoxycytidine Kinase mRNA in Cells Resistant to Antitumor Cytosine Nucleosides
• Nucleosides and Nucleotides. 186. Synthesis and Biological Activities of Pyrimidine Carbocyclic Nucleosides with a Hydroxyamino Group Instead of a Hydroxymethyl Group at the 4'-Position of the Sugar Moiety
• New Neplanocin Anallogues. VIII. Synthesis and Biological Activity of 6'-C-Ethyl, -Ethenyl, and -Ethynyl Derivatives of Neplanocin A
• In Vitro and in Vivo Antitumor Activity of a Novel Nucleoside, 4'-Thio-2'-deoxy-2'-methylidenecytidine
• Synthesis of N-Glycolyl-8-O-sulfoneuraminic Acid
• Synthesis of Fluorescent 4-Methyl-7-thiocoumaryl S-Glycosides of Sialic Acid
• Facile Synthesis of 4-Acylamino-2,6-anhydro-2,3,4-trideoxy-D-glycero-D-galacto-non-2-enoic Acids
• Capacity Improvement of Multihop Inter-Vehicle Communication Networks by STBC Cooperative Relaying(Advances in Ad Hoc Mobile Communications and Networking)
• Cytotoxic Principles of a Bangladeshi Crude Drug, Akond Mul (Roots of Calotropis gigantea L.)
• Synthesis and Biological Evaluation of Phosphonopyrimidine and Phosphonopurine Ribonucleosides(Medeicinal Chemistry,Chemical)
• Pregnane-Type Steroids from the Inedible Mushroom Thelephora terrestris
• Tyromycic Acids F and G: Two New Triterpenoids from the Mushroom Tyromyces fissilis
• Curtisians M-Q: Five Novel p-Terphenyl Derivatives from the Mushroom Paxillus curtisii
• Two Novel Ravenelones from the Edible Mushroom Pulveroboletus ravenelii
• Prediction of Helical Screw Sense of Oligopeptides Containing Chiral α, α-Disubstituted Amino Acids
• Synthesis and Anti-HIV-1 and Anti-HCMV Activity of 1-Substituted 3-(3,5-Dimethylbenzyl) uracil Derivatives
• ANTITUMOR ACTIVITY OF AQUEOUS EXTRACTS OF MARIRE ANIMALS
• EFFECT OF SERUM FROM MICE TREATED WITH ANTITUMOR POLYSACCHARIDE ON EXPRESSION OF CYTOTOXICITY BY MOUSE PERITONEAL MACROPHAGES
• Superoxide Anion Generation via Electron-Transfer Oxidation of Catechin Dianion by Molecular Oxygen in an Aprotic Medium
• Immunohistological Study of the Localization of Collagen Types I-XI in Bovine Term Placenta
• Immunohistological Study of the Localization of Collagen Types I-XI in Bovine Term Placenta
• Russujaponols G-L, Illudoid Sesquiterpenes, and Their Neurite Outgrowth Promoting Activity from the Fruit Body of Russula japonica
• Novel Abietane Diterpenoids and Aromatic Compounds from Cladonia rangiferina and Their Antimicrobial Activity against Antibiotics Resistant Bacteria
• Biotransformation of hinesol Isolated from the Crude Drug Atractylodes Iancea by Aspergillus niger and Aspergillus cellulosae
• Stereoselective Epoxidation of Acyclic Allylic Ethers Using Ketone-Oxone^ System
• Reduction of human T-cell leukemia virus type-1 infection in mice lacking nuclear factor-κB-inducing kinase
• Synthesis, Conformation, and Chemical Properties of New Mini Parallel Double-Stranded Peptides Conjugated with -Phe-Phe- and -Phe-Phe-X- Sequences
• Overexpression of Glyceraldehyde-3-phospahe Dehydrogenase Is Not Involved in 5-Hydroxytryptamine (5-HT)-Induced Necrosis in Cultured Cerebrocortical Neurons(Pharmacology)
• Insight into Acid-Mediated Asymmetric Spirocyclization in the Presence of a Chiral Diol
• Antisweet Natural Products. XV. Structures of Jegosaponins A-D from Styrax japonica SIEB. et ZUCC.
• Pregnane Glygosides, Gymnepregosides G-Q from the Roots of Gymnema alternifolium
• ortho-Halogeno Substituents Effect in Asymmetric Cyclization of 4-Aryl-4-pentenals Using a Rhodium Catalyst
• Enantio- and Diastereoselective Synthesis of N-[(1R, 2R, 3R, 4R)-2,3-Diacetoxy-4-(acetoxymethyl)cyclopentyl]acetamide, a Synthetic Key Intermediate of (+)-Cyclaradine
• Synthesis of Optically Active Bicyclo[3.3.0]octane Skeleton Using Transannular Reaction
• 2-Hydroxypropylated Cyclodextrins as a Sustained-Release Carrier for Fragrance Materials
• 3'-Fluorine-Substitution in 3'-Fluorocarbocyclic Oxetanocin A Augments the Drug's Inhibition of HHV-6B Propagation in Chronically Infected Cultures
• Computational Study on Helical Structure of α,α-Disubstituted Oligopeptides Containing Chiral α-Amino Acids
• ピペリジン骨格を有する非天然型アミノ酸の合成法 (特集 アミノ酸合成の先端研究)
• A Novel Method of Preparing Amine-Modifying C-4' Oxidized Nucleotide
• Cooperative Strand Invasion by Peptide Nucleic Acid
• Synthesis and Antitumor Activity of Phenyl Carbocyclic Oxetanocin and Related Compounds
• Synthesis and Antiviral Activity of 6-Chloropurine Arabinoside and Its 2'-Deoxy-2'-fluoro Derivative
• Design and Synthesis of Chiral Cyclic α,α-Disubstituted Amino Acid Having Azido Functions, and Its Oligopeptides
• イソバリンより構成されるホモペプチドの分子力学法によるコンフォメーション解析
• Hardness Controlled Enzymes and Electronegativity Controlled Enzymes : Role of an Absolute Hardness-Electronegativity (η-χ) Activity Diagram as a Coordinate for Biological Activities
• Design and Synthesis of Chiral α, α-Disubstituted Amino Acids and Conformational Study of Their Oligopeptides
• Conformation of Peptides Prepared from α-Ethylated α, α-Disubstituted Amino Acids
• Synthesis of Chiral Cyclic α, α-Disubstituted α-Amino Acid and Its Peptides
• Design of Short α-Helical Peptides for Transcriptional Inhibitor of Nuclear Receptor
• Computational Study on Conformation of Oligopeptides Containing α,α-Disubstituted Amino Acids
• Stabilized α-Helical Peptide-Catalyzed Asymmetric Epoxidation of Chalcone Derivatives
• Conformational Studies of Diastereomeric -Leu-Aib- Peptides
• Synthesis, Spectral Study and Crystal Structure of a Fluorescein Derivative, p-Methoxycarbonylphenyl Fluorone
• Aldol Condensation versus Conjugate Addition : Intramolecular Cyclization Using a Combination of Lewis Acid and 1,2-Diol
• α,α-ジ置換アミノ酸イソバリンおよびジエチルグリシンより構成されるホモペプチドの分子力学法によるコンフォメーション解析
• Design and Synthesis of Conformational Freedom Restricted Endomorphin-2 Analogues
• Design of Stable Helical Peptides
• Design of Stapled Helical Peptides for Catalytic Enantioselective Epoxidation of α,β-Unsaturated Ketones
• Synthesis and Conformational Analysis of Peptides Composed of Chiral Five-Membered Ring Amino Acids
• Synthesis of Chiral Five-membered Ring Amino Acids wtih an Azido Group, and Their Peptides
• Bio-imaging of hydroxyl radicals in plant cells using the fluorescent molecular probe rhodamine B hydrazide, without any pretreatment(PLANT BIOTECHNOLOGY)

もっと見る 閉じる

スポンサーリンク