Hardness Controlled Enzymes and Electronegativity Controlled Enzymes : Role of an Absolute Hardness-Electronegativity (η-χ) Activity Diagram as a Coordinate for Biological Activities
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概要
- 論文の詳細を見る
We found that absolute hardness-absolute electronegativity (η-χ) activity diagrams play an important role as a new coordinate of bioactivity in structure-activity relationships. In this paper, the η-χ activity diagram, focusing on the molecular mechanism of bioactive compounds is used to discuss two major problems. First, the potency of bioactivities for xenobiotics such as polychlorinated dibenzo-p-dioxins (PCDDs) 3 and polychlorinated biphenyls (PCBs) 4,were found to be strongly related to their absolute hardness (η). Second, the antibacterial activity of new quinolones such as norfloxacin 1 and enoxacin 2,was found to be strongly related to their absolute electronegativity (χ). These findings predict at least two chemical properties for a hardness-controlled or electronegativity-controlled enzyme.
- 公益社団法人日本薬学会の論文
- 1998-07-15
著者
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宮田 直樹
名古屋市立大学
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MIYATA Naoki
Division of Organic Chemistry, National Institute of Health Sciences
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Kobayashi Shigeki
Department of Medicine and Clinical Science, Yamaguchi University Graduate School of Medicine
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Tanaka Akira
Department of Health and Nutrition, College of Human and Environmental Studies, Kanto-Gakuin Univers
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KURIHARA Masaaki
Division of Organic Chemistry, National Institute of Health Sciences
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Miyata Naoki
Division Of Organic Chemistry National Institute Of Health Sciences
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Tanaka A
Faculty Of Pharmaceutical Sciences Tokyo University Of Science
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Kobayashi S
Eisai Research Institute Of Boston Inc.
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Kobayashi Shoichi
Laboratory Of Food And Health Science Department Of Agro-bioscience Faculty Of Agriculture Iwate Uni
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HAMASHIMA Hajime
Department of Microbiology, Showa Pharmaceutical University
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Kobayashi Shigeki
Department Of Analytical Chemistry Of Medicines Showa Phamaceutical University
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Kobayashi Shigeki
Department Of Analytical Chemistry Of Medicines Showa Pharmaceutical University
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Kobayashi Shigeki
Div. Of Analytical Chemistry Of Medicines Showa Pharmaceutical Univ.
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Kurihara M
Division Of Organic Chemistry National Institute Of Health Sciences
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Kurihara Masaaki
Division Of Organic Chemistry National Institute Of Health Sciences
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Miyata Naoki
Division Of Organic Chemistry
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Hamashima Hajime
Department Of Microbiology Showa Phamaceutical University
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Hamashima Hajime
Department Of Microbiology Showa College Of Pharmacy
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Tanaka Akira
Department Of Diagnostic Pathology Jichi Medical University
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TANAKA Akira
Department of Agricultural Chemistry, Faculty of Agriculture, Tohoku University
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