Stereo Structure-Controlled and Electronic Structure-Controlled Estrogen-Like Chemicals to Design and Develop Non-estrogenic Bisphenol A Analogs Based on Chemical Hardness Concept
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概要
- 論文の詳細を見る
The aim of this study was to elucidate the structure-activity relationship of bisphenol A (BPA) analogs using absolute hardness (η) and absolute electronegativity (χ) (chemical hardness) and to design a non-estrogen active BPA. To determine the structure-activity relationships of BPA analogs, we investigated MCF-7 cell proliferation stimulated by BPA analogs and an η-χ diagram based on the electronic structure of the BPA analogs. The results show that the actions of the environmental hormones BPA analogs have two chemical properties; (i) 'stereo structure-controlled' and (ii) 'electronic structure-controlled' estrogen-like chemical activities. Therefore, we designed and synthesized BPA analogs which do not possess these 2 characteristics, ((i) and (ii)), and demonstrate the non-estrogen activity of the analog.
- 公益社団法人日本薬学会の論文
- 2006-12-01
著者
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Kobayashi Shigeki
Department of Medicine and Clinical Science, Yamaguchi University Graduate School of Medicine
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YAMAMOTO Naoko
Department of Pharmacology, Faculty of Pharmaceutical Sciences, Nagasaki University
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Kobayashi Shoichi
Laboratory Of Food And Health Science Department Of Agro-bioscience Faculty Of Agriculture Iwate Uni
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Kobayashi Shigeki
Department Of Analytical Chemistry Of Medicines Showa Phamaceutical University
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Yamamoto Naoko
Department Of Anesthesiology Osaka Dental University
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SHINOHARA Hidemi
Department of Analytical Chemistry of Medicines, Showa Pharmaceutical University
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TABATA Kyoko
Department of Analytical Chemistry of Medicines, Showa Pharmaceutical University
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MIYAI Akira
Space Environmental Technology, Corporation
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Miyai Akira
Space Environmental Technology Corporation
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Tabata Kyoko
Department Of Analytical Chemistry Of Medicines Showa Pharmaceutical University
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Shinohara Hidemi
Department Of Analytical Chemistry Of Medicines Showa Pharmaceutical University
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Yamamoto Naoko
Department Of Analytical Chemistry Of Medicines Showa Pharmaceutical University
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