Synthesis of optically Active Deoxytazettine Neomethine

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概要

• 論文の詳細を見る

• The structure of deoxytazettine neomethine (I), derived from tazettine (III) via 5 steps, was confirmed by synthesis of its optically active and racemic forms. A key step in the synthesis, conversion of 2'-bromomethyl-4', 5'-methylenedioxy-2-biphenylcarbal-dehyde (VI) to 7-cyano-5,7-dihydro-2,3-methylenedioxydibenz [c, e] oxepin (VII), was achieved by employing a novel method which had been developed for synthesis of 5-cyano-5,7-dihydrodibenz [c, e] oxepin (V). The nuclear magnetic resonance spectra of the neomethine (I) and its synthetic intermediates were discussed.

• 公益社団法人日本薬学会の論文
• 1976-04-25

著者

• 小林 茂

  Faculty Of Home Economics Shikoku University

• 木原 勝

  徳島大学薬学部薬学研究科医療薬学専攻

• 橋本 敏弘

  Faculty of Pharmaceutical Sciences, Tokushima Bunri University

• Kobayashi S

  Eisai Research Institute Of Boston Inc.

• 新宮 徹朗

  神院大・薬

• 新宮 徹朗

  京都大学薬学部

• Kobayashi Shoichi

  Laboratory Of Food And Health Science Department Of Agro-bioscience Faculty Of Agriculture Iwate Uni

• Kihara M

  Graduate School Of Pharmaceutical Sciences The University Of Tokushima

• 新宮 徹朗

  School Of Pharmacy Kobe-gakuin University

• Kobayashi Shigeki

  Div. Of Analytical Chemistry Of Medicines Showa Pharmaceutical Univ.

• 橋本 敏弘

  徳島文理大学薬学部

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