Syntheses of Apogalanthamine Analogs as α-Adrenergic Blocking Agents

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概要

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• The apogalanthamine analogs, 10,11-methylenedioxy-, 10,11-dimethoxy-, and 11,12-dimethoxy-5,6,7,8-tetrahydrodibenz [c, e] azocines (2,5,and 7,respectively) and their N-substituted derivatives (1,3,4,6,8,and 9) as α-adrenergic blocking agents, and the related compounds, 2,3-dimethoxy-, 2,3-methylenedioxy-, and 11-methoxy-5,6,7,8-tetrahydrodibenz [c, e] azocines (10,11,and 12,respectively) were synthesized by intramolecular cyclization of the corresponding amino-alcohols (30a-f) via the corresponding bromo-amines (16a-f). The preparation of the nitrovinyl compounds (19a-f) as startnig materials for the amino-alcohols was investigated. The conformation of these azocines was discussed in relation to nuclear magnetic resonance spectral data.

• 公益社団法人日本薬学会の論文
• 1977-12-25

著者

• 小林 茂

  Faculty Of Home Economics Shikoku University

• 木原 勝

  Faculty Of Pharmaceutical Sciences The University Of Tokushima

• 木原 勝

  徳島大学薬学部薬学研究科医療薬学専攻

• 松本 宏

  徳島大学薬学部

• 志津 暁

  Faculty of Pharmaceutical Sciences, Tokushima University

• 片山 定

  Faculty of Pharmaceutical Sciences, Tokushima University

• 池田 治吉

  Faculty of Pharmaceutical Sciences, Tokushima University

• 北広 和雄

  Faculty of Pharmaceutical Sciences, Tokushima University

• 松本 宏

  Faculty of Pharmaceutical Sciences, Tokushima University

• 片山 定

  Faculty Of Pharmaceutical Sciences Josai University

• 志津 暁

  Faculty Of Pharmaceutical Sciences Tokushima University

• 池田 治吉

  Faculty Of Pharmaceutical Sciences Tokushima University

• 北広 和雄

  Faculty Of Pharmaceutical Sciences Tokushima University

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