Cleavage of the Methylenedioxy Ring. III. Cleavage with Sodium Benzyloxide in Dimethyl Sulfoxide
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概要
- 論文の詳細を見る
Cleavage of the methylenedioxy ring in aromatic formyl (1-3), nitro (4 and 5), and acetyl (30) compounds with N-sodium benzyloxide-benzyl alcohol in dimethyl sulfoxide gave 3-hydroxybenzene derivatives (19,22-24,26,27,and 33). In the case of the acetyl compound 30,the 4-hydroxybenzene derivative (34) was also obtained as a minor product. Regioselective cleavage of the ring in aromatic compounds having electron-withdrawing groups with nucleophilic oxide anions is discussed. Cleavage of the ring in 1-5 and 30 with 2N sodium methoxide in dimethyl sulfoxide-dimethylformamide was found to be useful for the praotical preparation of 3-hydroxybenzene derivatives (6-10 and 31).
- 社団法人日本薬学会の論文
- 1982-05-25
著者
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小林 茂
Faculty Of Home Economics Shikoku University
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今倉 康宏
Faculty of Sciences, Naruto University of Education
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沖本 和人
Technological Development Laboratories, Fujisawa Pharmaceutical Co., Ltd.
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沖本 和人
Faculty of Pharmaceutical Sciences, Tokushima University
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今倉 康宏
Faculty Of Pharmaceutical Sciences The University Of Tokushima
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沖本 和人
Technological Development Laboratories Fujisawa Pharmaceutical Co. Ltd.
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