Alpha-adrenolytic Activities of N-Benzyl-β-phenethylamine Derivatives on Isolated Smooth Muscles
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概要
- 論文の詳細を見る
Previously N-methyl-5,6,7,8-tetrahydrodibenz [c, e] azocine (DA-VIII-Me) and N-methyl-10,11-methylenedioxy-5,6,7,8-tetrahydrodibenz [c, e] azocine (DA-VIII-M-Me) were found to have strong α-adrenolytic activities ; the pA_s values were 8.76 and 7.71,respectively. N-Benzyl-N-methyl-β-phenethylamine (BMPA) and N-benzyl-N-methyl-3,4-methylenedioxy-β-phenethylamine (BMPA-MO) which resemble DA-VIII-Me and DA-VIII-M-Me in structure but with the azocine ring opened at the biphenyl bond, were synthesized. It was found that the α-adrenolytic activities of these compounds on rat aortic strips were much less than those of DA-VIII-Me and DA-VIII-M-Me ; the pA_2 values for BMPA and BMPA-MO were 6.79 and 5.78,respectively. Thus it was concluded that the dibenz [c, e] azocine structure of the latter compounds was important for their α-adrenolytic activities. It was also found that BMPA and BMPA-MO had a dual action, producing a moderately strong long-lasting contraction and inhibiting the contractile responses to various stimulants of isolated smooth muscles.
- 公益社団法人日本薬学会の論文
- 1978-12-25
著者
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小林 茂
Faculty Of Home Economics Shikoku University
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木原 勝
Faculty Of Pharmaceutical Sciences The University Of Tokushima
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石田 行雄
Faculty Of Pharmaceutical Sciences Tokushima University
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笠原 宏子
Faculty Of Pharmaceutical Sciences Tokushima University
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