Photochemical Syntheses of Apogalanthamine Analogs as α-Adrenergic Blocking Agents
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概要
- 論文の詳細を見る
The apogalanthamine analogs, 10,11-methylenedioxy- and 10,11-dimethoxy-5,6,7,8-tetrahydrodibenz [c, e] azocines (1 and 2,respectively) as α-adrenergic blocking agents were synthesized by photolysis of N-benzyl-2-iodo-4,5-methylenedioxy- and N-benzyl-2-iodo-4,5-dimethoxy-β-phenethylamine (20 and 21,respectively). 2,3-Methylenedioxy-, and 2,3-dimethoxy-5,6,7,8-tetrahydrodibenz [c, e] azocine (9 and 10,respectively) were obtained similarly from N-(2-iodo-4,5-methylenedioxybenzyl)- and N-(4,5-dimethoxy-2-iodobenzyl)-β-phenethylamine (18 and 19,respectively). The yields of 9 and 10 from the iodo-amines (18 and 19) having an iodine atom in the benzyl group were found to be better than those of 1 and 2 from iodides 20 and 21 respectively having a halogen atom in the phenethyl group.
- 公益社団法人日本薬学会の論文
- 1978-01-25
著者
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小林 茂
Faculty Of Home Economics Shikoku University
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木原 勝
Faculty Of Pharmaceutical Sciences The University Of Tokushima
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