Synthesis of 2'-Cyanomethyl-2-biphenylcarboxylic Acid

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概要

• 論文の詳細を見る

• The reaction product of diphenide (I) with potassium cyanide, previously described as 2'-cyanomethyl-2-biphenylcarboxylic acid (II), is in fact a phenanthrol derivative (V). The acid (II) is an intermediate in the reaction. These facts were proved by synthesis of II from I by an alternative, unambiguous method. In the last step of the synthesis, only boron tribromide is effective for hydrolysis of the ester (IX). This is the first time it has been employed as a hydrolyzing agent for an ester. In contrast to previous results, 9-phenanthrol (III) was found to be a product of the calcium salt of V.

• 公益社団法人日本薬学会の論文
• 1972-04-25

著者

• 小林 茂

  Faculty Of Home Economics Shikoku University

• 木原 勝

  徳島大学薬学部薬学研究科医療薬学専攻

• Kobayashi S

  Eisai Research Institute Of Boston Inc.

• Kobayashi Shoichi

  Laboratory Of Food And Health Science Department Of Agro-bioscience Faculty Of Agriculture Iwate Uni

• 小林 茂

  Pharmaceutical Faculty, University of Nagasaki

• 北村 皖司

  徳島大学薬学部

• 北村 皖司

  Pharmaceutical Faculty, University of Tokushima

• 三浦 明

  Pharmaceutical Faculty, University of Tokushima

• 福田 美代子

  Pharmaceutical Faculty, University of Tokushima

• 木原 勝

  Pharmaceutical Faculty, University of Tokushima

• 三浦 明

  Pharmaceutical Faculty University Of Tokushima

• Kobayashi Shigeki

  Department Of Analytical Chemistry Of Medicines Showa Pharmaceutical University

• Kihara M

  Graduate School Of Pharmaceutical Sciences The University Of Tokushima

• Kobayashi Shigeki

  Div. Of Analytical Chemistry Of Medicines Showa Pharmaceutical Univ.

• 福田 美代子

  Pharmaceutical Faculty University Of Tokushima

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