Toxicity of Dioxins : Role of an Absolute Hardness-Adsolute Electronegativity Diagram (η-χ Diagram) as a New Measure in Risk Assessment
スポンサーリンク
概要
- 論文の詳細を見る
The differences in biological activities among polychlorinated dibenzo-p-dioxins (dioxins) are strongly dependent on the substitution pattern of chlorine at various positions on the parent dibenzo-p-dioxin molecule. The absolute hardness, η, of dioxins shows a good correlation with the potency of biological activity and the chlorine substitution pattern. The result means that the soft dioxins have a small HOMO-LUMO gap, and are more toxic than the hard dioxins. Therefore, the values of absolute hardness, η, of dioxins can be used to predict their toxic potency (dioxin hardness). Moreover, we show that the absolute hardness-absolute electronegativity (η-χ) diagrams, as an activity coordinate, play an important role as a new measure in the assessment of the toxicity and potency of the biological activity of dioxins.
- 社団法人日本薬学会の論文
- 1995-10-15
著者
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小林 茂樹
昭和薬大
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田中 彰
Graduate School Of Agricultural Science Tamagawa University
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鮫島 圭一郎
富士通(株)幕張システムラボラトリ
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小林 茂樹
Showa College of Pharmaceutical Science
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鮫島 圭一郎
Department of Computer Chemistry Systems, Fujitsu, Limited
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石井 耀子
Showa College of Pharmaceutical Science
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田中 彰
Department of Computer Chemistry Systems, Fujitsu, Limited
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Kobayashi Shigeki
Department Of Analytical Chemistry Of Medicines Showa Pharmaceutical University
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Ishi Y
Showa College Of Pharmaceutical Science
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Kobayashi Shigeki
Div. Of Analytical Chemistry Of Medicines Showa Pharmaceutical Univ.
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田中 章
昭和薬大
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