Topology Effect for DNA Structure of Cisplatin : Topological Transformation of Cisplatin-Closed Circular DNA Addusts by DNA Topoisomerase I
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概要
- 論文の詳細を見る
The reaction of cis-Pt(NH_3)_2Cl_2(cis-DDP)-closed circular DNA adducts with DNA topoisomerse I(topo I)were studied by electron microscopy. We identified unique topoisomers such as a singly-linked catenane (2^2_1), trefoil (3_1), and dimetric catenane (2^2_1), etc., by analysis with electron micrographs. These unique recombination products resulted from cis-DDP-intra-twisting looped DNA adducts by DNA topo I, and the products could be explained a new mechanism based on an odd-even number rule. Our results suggest a new model on the working mechanisms for DNA topology of cis-DDP which enhances the recombination of DNA. Based on our results, we propose the topological idea that the yields of a mini closed circular DNA and pseudo trefoil DNA, etc., can be expected by reaction of cis-DDP-DNA-histone complexes with DNA topo I in the body.
- 公益社団法人日本薬学会の論文
- 1999-06-15
著者
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Kobayashi Shigeki
Department of Medicine and Clinical Science, Yamaguchi University Graduate School of Medicine
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Tanaka Akira
Department of Health and Nutrition, College of Human and Environmental Studies, Kanto-Gakuin Univers
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Tanaka A
Faculty Of Pharmaceutical Sciences Tokyo University Of Science
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Kobayashi S
Eisai Research Institute Of Boston Inc.
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Kobayashi Shoichi
Laboratory Of Food And Health Science Department Of Agro-bioscience Faculty Of Agriculture Iwate Uni
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Kobayashi Shigeki
Department Of Analytical Chemistry Of Medicines Showa Phamaceutical University
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Kobayashi Shigeki
Department Of Analytical Chemistry Of Medicines Showa Pharmaceutical University
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Kobayashi Shigeki
Div. Of Analytical Chemistry Of Medicines Showa Pharmaceutical Univ.
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HAMASHIMA Hajime
Microbiology, Showa Pharmaceutical University
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Arai Taketoshi
Microbiology Showa College Of Pharmaceutical Sciences
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Furukawa M
Tokyo Univ. Pharmacy & Life Sci. Tokyo Jpn
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FURUKAWA Mitsue
Department of Drug Analysis, Showa College of Pharmaceutical Sciences
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DOHI Chikako
Department of Drug Analysis, Showa College of Pharmaceutical Sciences
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Hamashima Hajime
Department Of Microbiology Showa Phamaceutical University
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Dohi Chikako
Department Of Drug Analysis Showa College Of Pharmaceutical Sciences
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Tanaka Akira
Department Of Diagnostic Pathology Jichi Medical University
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TANAKA Akira
Department of Agricultural Chemistry, Faculty of Agriculture, Tohoku University
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