A Dental Clinical Study for 12 Cases of SAPHO Syndrome with Biomedical Research on Trace Elements(International Symposium of Maxillofacial and Oral Regenerative Biology in Okayama 2005)

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SAPHO syndrome is characterized by bone-inflammation with or without skin lesions. We reported about clear effect of oral-treatments for skin lesion of palmoplantar pusturosis. This time, for a first investigation into a relation between oral diseases and pathogenesis of SAPHO syndrome, we made a clinical study for oral-treatments on 12 patients of SAPHO syndrome with palmoplantar pusturosis and biomedical research on trace elements in blood. Dental treatments (treatment for dental chronic focuses, dental metal removal by patch test) were done for 12 patients of SAPHO sindrome with skin, bone and joint symptoms. By the dental treatments, the skin lesion had been cured or decreased remarkably in all cases, and pain of bone and joints had been cured in all cases. The blood samples from 7 patients with SAPHO Syndrome were analyzed for trace metals. The analyzed trace metals were serum zinc serum copper serum iron blood selenium and blood mercury. The serum copper level was significantly high, the serum zinc level was significantly low and the blood selenium level was significant low than healthy control. The other trace metals in the blood showed no remarkable change. These result suggests a possibility intra-oral-focus, dental-metals and trace metals has some relation to pathogenesis of SAPHO syndrome.
硬組織再生生物学会の論文