Total Synthesis of (-)-Decarestrictine J
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概要
- 論文の詳細を見る
The synthesis of (-)-decarestrictine J (1), a novel inhibitor of the cholesterol biosynthesis, is described. (-)-Epoxy alcohol 6, which was obtained by the Sharpless asymmetric epoxidation of trans-allylic alcohol 13, was converted to bromoacetoxy aldehyde 3 through a nine-step sequence. The samarium(II)iodide-promoted intramolecular Reformatsky reaction of 3 and subsequent oxidation afforded keto lactone 21 which, by treating with trimethylsilyl bromide, provided (-)-decarestrictine J (1).
- 社団法人日本農芸化学会の論文
- 1995-09-23
著者
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Tanaka Akira
Department of Health and Nutrition, College of Human and Environmental Studies, Kanto-Gakuin Univers
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YAMADA Shinya
Department of Physics, The University of Tokyo
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ORITANI Takayuki
Department of Applied Biological Chemistry, Faculty of Agriculture
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Yamada Shinya
Department Of Applied Biological Chemistry Faculty Of Agriculture Tohoku University
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Oritani Takayuki
Department Of Agricultural Chemistry Faculty Of Agriculture Tohoku University
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Tanaka Akira
Department Of Diagnostic Pathology Jichi Medical University
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TANAKA Akira
Department of Agricultural Chemistry, Faculty of Agriculture, Tohoku University
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