DNA Topology on an Increase in Positive Writhing Number of DNA : Conformation Changes in the Time Course of cis-Diamminedichloroplatinum(II)-DNA Adducts
スポンサーリンク
概要
- 論文の詳細を見る
We slum that the topological significance of the gel mobility of tis-diamminedichloroplatinum(II) (DDP) closed circular DNA (ccDNA) adducts decreases with reaction time, until a point at which it joins relaxed DNA, and that the mobility of the adducts increases again. There is no relationship between the relative length of the adducts and the gel mobility. Although the significance of the decrease of gel mobility is due to the unwinding of cis-DDP-DINA (or trans-DDP-DNA) adducts, the conformational significance of the subsequent increase in mobility is unclear. To elucidate the conformational significance for unwinding of the adducts, we measured the writhing number (Wk) of the adducts using electron microscopy and analyzed the topological states of cis-DDP (or trans-DDP) adducts based on the White rule, Lk=Wk+Tk. Where, Lk and Tk represent the linking and twisting number in the ring, respectively. From the data, we found that the Wk of cis-DDP-ccDNA adducts in comparison with trans-DDP-ccDNA adducts increases from a negative to a positive number with time. This suggests that cis-DDP plays a role in the change of the topological state of ccDNA. In the abstraction of platinum from the adducts with CN^- ion, the differences in both topological states may explain why Pt in trans-DDP is abstracted more easily than in cis-DDP. To explain the abstraction of Pt ion, we also discuss the findings based on the thermodynamic cycle in a intermolecular crosslink model Pt(NH_3)_2(guanine)^<2+>_2→Pt(CN)^<2->_4 using the Pt parametrized PM3 method.
- 公益社団法人日本薬学会の論文
- 2001-09-01
著者
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Nakamura Yoshihide
Department of Pediatric Cardiology, Japanese Red Cross Society Wakayama Medical Center
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Kobayashi Shigeki
Department of Medicine and Clinical Science, Yamaguchi University Graduate School of Medicine
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Tanaka Akira
Department of Health and Nutrition, College of Human and Environmental Studies, Kanto-Gakuin Univers
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Tanaka A
Faculty Of Pharmaceutical Sciences Tokyo University Of Science
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SASATSU Masanori
Department of Microbiology, School of Pharmacy, Tokyo University of Pharmacy and Life Science
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Kobayashi S
Eisai Research Institute Of Boston Inc.
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Asano K
Department Of Urology Jikei University School Of Medicine
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Asano Koji
Department Of Urology Jikei University School Of Medicine
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Kobayashi Shoichi
Laboratory Of Food And Health Science Department Of Agro-bioscience Faculty Of Agriculture Iwate Uni
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OHISHI Yukihiko
Department of Urology, Jikei University, School of Medicine
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Ohishi Y
Department Of Urology Jikei University School Of Medicine
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Ohishi Yukihiko
Department Of Urology Jikei University
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Kobayashi Shigeki
Department Of Analytical Chemistry Of Medicines Showa Phamaceutical University
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Kobayashi Shigeki
Department Of Analytical Chemistry Of Medicines Showa Pharmaceutical University
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Kobayashi Shigeki
Div. Of Analytical Chemistry Of Medicines Showa Pharmaceutical Univ.
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Sasatsu Masanori
Department Of Microbiology School Of Pharmacy Tokyo University Of Pharmacy And Life Science
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Nakamura Yoshihide
Departments Of Analytical Chemistry Of Medicines Slwwa Pharmaceutical University
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MAEHARA Tamae
Departments of Analytical Chemistry of Medicines Slwwa Pharmaceutical University
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HAMASHIMA Hajime
Microbiology, Showa Pharmaceutical University
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Asano Koji
Department Of Surgery Tottori University School Of Medicine
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Nakamura Yoshihide
Department Of Chemistry Faculty Of Science Science University Of Tokyo
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Hamashima Hajime
Department Of Microbiology Showa Phamaceutical University
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Asano Koji
Department Of Laboratory Medicine Shinshu University School Of Medicine
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Tanaka Akira
Department Of Diagnostic Pathology Jichi Medical University
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TANAKA Akira
Department of Agricultural Chemistry, Faculty of Agriculture, Tohoku University
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