Defective Ca^<2+> Cycling as a Key Pathogenic Mechanism of Heart Failure(Molecular Mechanisms)
スポンサーリンク
概要
- 論文の詳細を見る
Structural and functional alterations in the Ca^<2+> regulatory proteins present in the sarcoplasmic reticulum (SR) have recently been shown to play a crucial role in the pathogenesis of heart failure (HF), and lethal arrhythmia as well. Chronic activation of the sympathetic nervous system induces abnormalities in both the function and structure of these proteins. For instance, the diastolic Ca^<2+> leak through the SR Ca^<2+> release channel (ryanodine receptor) reduces the SR Ca^<2+> content, inducing contractile dysfunction. Moreover, the Ca^<2+> leak provides a substrate for delayed afterdepolarization that leads to lethal arrhythmia. There is a considerable body of evidence regarding the role of Ca^<2+> cycling abnormality in HF.
- 社団法人日本循環器学会の論文
- 2008-09-20
著者
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Ikeda Yasuhiro
Department of Medicine and Clinical Science, Division of Cardiology, Yamaguchi University Graduate S
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Matsuzaki Masunori
Department of Medicine and Clinical Science, Division of Cardiology, Yamaguchi University Graduate S
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YAMAMOTO TAKESHI
Department of Gastroenterology, Tohoku Koseinenkin Hospital
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Yamamoto Takeshi
Department Of Medicine And Clinical Science Division Of Cardiology Yamaguchi University Graduate Sch
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Yano Masafumi
Department Of Medicine And Clinical Science Division Of Cardiology Yamaguchi University Graduate Sch
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Ikeda Yasuhiro
山口大学 医学系研究科
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Ikeda Yasuhiro
Department Of Medicine And Clinical Science Yamaguchi University Graduate School Of Medicine
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Ikeda Yasuhiro
Department Of Medicine And Clinical Science Division Of Cardiology Yamaguchi University Graduate Sch
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Kobayashi Shigeki
Department of Medicine and Clinical Science, Yamaguchi University Graduate School of Medicine
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Kobayashi Shigeki
Yamaguchi University Graduate School of Medicine
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Ikeda Yasuhiro
Division Of Cardiology Department Of Medicine And Clinical Science Yamaguchi University Graduate Sch
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Ikeda Yasuhiro
山口大学 医学系研究科器官病態内科学
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Ikeda Yasuhiro
Department Of Dental Science Institute Of Personalized Medical Science Health Sciences University Of
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Matsuzaki Masunori
Department Of Cardiology Kyushu Kousei-nenkin Hospital
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Yano Masafumi
山口大学 医学系研究科器官病態内科学
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TAKADA YASUHARU
Saijo Central Hospital
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Matsuzaki M.
Yamaguchi University School of Medicine
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Yamamoto Takeshi
Department Of Medicine And Clinical Science Yamaguchi University Graduate School Of Medicine
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Kobayashi Shigeki
Division Of Cardiology Department Of Medicine And Clinical Science Yamaguchi University Graduate Sch
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Kobayashi Shigeki
Department Of Analytical Chemistry Of Medicines Showa Phamaceutical University
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Takahashi Yojiro
Division Of Cardiovascular Medicine Department Of Medical Bioregulation Yamaguchi University School
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Matsuda Yasuo
The Second Division Department Of Internal Medicine Yamaguchi University School Of Medicine
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Ikeda Yasuhiro
Dept. Of Medical Bioregulation Division Of Cardioventricular Medicine Yamaguchi University School Of
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Mochizuki Mamoru
Division Of Cardiology Department Of Medicine And Clinical Science Yamaguchi University Graduate Sch
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Miyahara Mitsuo
Dept. Of Intern. Med. (section 2) Sapporo Med. Coll.
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Matsubara Mitsunobu
Division Of Molecular Medicine Tohoku University Graduate School Of Medicine
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Mochizuki Mamoru
Department Of Medicine And Clinical Science Division Of Cardiology Yamaguchi University Graduate Sch
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Matsuzaki Masunori
Japanese Circulation Society Guideline Preparation Group Myocarditis
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Matsuda Yasuo
Department Of Cardiovascular Medicine Yamaguchi University Graduate School Of Medicine
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Yano Masafumi
Department Of Cardiovascular Medicine Yamaguchi University School Of Medicine
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Yamamoto Takeshi
Division Of Cardiovascular Medicine Department Of Medical Bioregulation Yamaguchi University School
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Matsuaki Masunori
Department Of Medical Bioregulation Division Of Cardiovascular Medicine Yamaguchi University School
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Yano Masafumi
Department Of Applied Chemistry Osaka Institute Of Technology
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Ikeda Yasuhiro
Department Of Cardiovascular Medicine Yamaguchi University
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Kobayashi Shigeki
Department Of Medicine And Clinical Science Yamaguchi University Graduate School Of Medicine
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Yamamoto Takeshi
Department Of Gastroenterology Tohoku Koseinenkin Hospital
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Kobayashi Shigeki
Second Dept. Of Internal Med. Yamaguchi University
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Takahashi Yojiro
The Second Division Of Internal Medicine Yamaguchi University School Of Medicine
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Yamamoto Takeshi
Department Of Fixed Prosthodontics Institute Of Health Biosciences The University Of Tokushima Gradu
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Murakami Masanori
Department Of Surgery And Clinical Science Division Of Cardiac Surgery Yamaguchi University Graduate
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Yamamoto Takeshi
Division Of Cardiology Tokuyama Central Hospital
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Yamamoto Takeshi
Department Of Anesthesiology Nagoya City University Medical School
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Matsuzaki Masunori
Division Of Cardiology Department Of Medicine And Clinical Science Yamaguchi University Graduate Sch
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Murakami Masanori
The Second Division Of Internal Medicine Yamaguchi University School Of Medicine
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Yamamoto Takeshi
Department Of Agricultural Biochemistry And Biotechnology Tottori University
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Matsuzaki Masunori
The Depart. Of Int. Med. Yamaguchi Univers. School Of Med.
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