Effect of Ischemic Preconditioning and Mitochondrial K_<ATP> Channel Openers on Chronic Left Ventricular Remodeling in the Ischemic-Reperfused Rat Heart
スポンサーリンク
概要
- 論文の詳細を見る
The influence of ischemic preconditioning (IP) and mitochondrial ATP-sensitive potassium (mito-KATP) channel openers on chronic left ventricular (LV) remodeling remains unknown, so the effect of IP and mito-K_<ATP> channel openers on the LV pressure-volume curve was assessed in rats subjected to 30min ischemia followed by a 3 week reperfusion. Infarct size was histologically determined at 3 weeks after reperfusion. The LV pressure-volume curve was significantly shifted left by IP, diazoxide and nicorandil compared with the controls. These effects were blocked by the selective mito-K_<ATP> channel blocker 5-hydroxydecanoate. The LV remodeling and the infarct size at 3 weeks after reperfusion correlated well, indicating that the reduction of LV remodeling in the ischemic-reperfused model was strongly influenced by attenuation of the ischemic injury. LV remodeling in the chronic phase is attenuated by IP and mito-K_<ATP> channel openers with concomitant reduction of infarct size.
- 社団法人日本循環器学会の論文
- 2002-03-20
著者
-
Miura Toshiro
Department of Medicine and Clinical Science, Division of Cardiology, Yamaguchi University Graduate S
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Kawamura Shuji
Department of Medicine and Clinical Science, Division of Cardiology, Yamaguchi University Graduate S
-
Ikeda Yasuhiro
Department of Medicine and Clinical Science, Division of Cardiology, Yamaguchi University Graduate S
-
Matsuzaki Masunori
Department of Medicine and Clinical Science, Division of Cardiology, Yamaguchi University Graduate S
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Miura Toshiro
Department Of Medicine And Clinical Science Yamaguchi University Graduate School Of Medicine
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Kawamura Shuji
Department Of Medicine And Clinical Science Division Of Cardiology Yamaguchi University Graduate Sch
-
Okamura Takayuki
Department of Medicine And Clinical Science, Yamaguchi University Graduate School of Medicine
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Harada Nozomu
The Department of Cardiovascular Medicine, Yamaguchi University Graduate School of Medicine
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Kametani Ryosuke
Department of Cardiovascular Medicine, Yamaguchi University Graduate School of Medicine
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Harada Nozomu
Department of Cardiovascular Medicine, Yamaguchi University School of Medicine
-
Dairaku Yuka
Department of Cardiovascular Medicine, Medical Bioregulation, Yamaguchi University School of Medicin
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Kimura Masayasu
Department of Cardiovascular Medicine, Medical Bioregulation, Yamaguchi University School of Medicin
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Iwamoto Hiroshi
Department of Cardiovascular Medicine, Medical Bioregulation, Yamaguchi University School of Medicin
-
Yamada Michio
Department of Cardiovascular Medicine, Medical Bioregulation, Yamaguchi University School of Medicin
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Iwatate Mitsuo
Department of Cardiovascular Medicine, Medical Bioregulation, Yamaguchi University School of Medicin
-
Iida Hiroshi
Division Of Cardiology Tokuyama Central Hospital
-
Kametani Ryosuke
The Department Of Cardiovascular Medicine Yamaguchi University Graduate School Of Medicine
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Kimura Masayasu
綜合病院社会保険徳山中央病院 循環器内科
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Kawamura Shuji
Division Of Cardiology Department Of Medicine And Clinical Science Yamaguchi University Graduate Sch
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Kawahara Shinji
Devision Of Cardiology Department Of Medicine And Clinical Science Yamaguchi University School Of Me
-
Kanemoto Masashi
滋賀医科大学 呼吸循環器内科
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Kawamura Shuji
Department Of Internal Medicine Hyogo Prefectural Nishinomiya Hospital
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Dairaku Yuka
Division Of Cardiovascular Medicine Department Of Medical Bioregulation Yamaguchi University School
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Dairaku Yuka
Department Of Cardiovascular Medicine Medical Bioregulation Yamaguchi University School Of Medicine
-
Harada Nozomu
Department Of Cardiovascular Medicine Yamaguchi University Graduate School Of Medicine
-
Harada Nozomu
The Department Of Cardiovascular Medicine Yamaguchi University Graduate School Of Medicine
-
Yamada Michio
Yamaguchi University School Of Medicine Department Of Molecular Cardiovascular Biology
-
Ikeda Yasuhiro
Department Of Dental Science Institute Of Personalized Medical Science Health Sciences University Of
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Iwatate Mitsuo
Department Of Cardiovascular Medicine Medical Bioregulation Yamaguchi University School Of Medicine
-
Kimura Masayasu
Department Of Cardiovascular Medicine Medical Bioregulation Yamaguchi University School Of Medicine
-
Miura Toshiro
Second Department Of Internal Medicine Yamaguchi University School Of Mediciney
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Matsuzaki Masunori
Department Of Cardiology Kyushu Kousei-nenkin Hospital
-
Matsui Toshihiro
Division Of Cardiology Department Of Medicine And Clinical Science Yamaguchi University Graduate Sch
-
Iwamoto Hiroshi
Division Of Cardiology Tokuyama Central Hospital
-
Iwamoto Hiroshi
Department Of Cardiovascular Medicine Medical Bioregulation Yamaguchi University School Of Medicine
-
Okamura Takayuki
Department Of Medicine And Clinical Science Yamaguchi University Graduate School Of Medicine
-
Okamura Takayuki
Department Of Immunochemistry Faculty Of Pharmaceutical Sciences Okayama University
-
Okamura Takayuki
Division Of Cardiology Department Of Medicine And Clinical Science Yamaguchi University Graduate Sch
-
Kawahara Shinji
Department Of Cardiovascular Medicine Yamaguchi University Graduate School Of Medicine
-
Dairaku Yuka
山口大学 循環器病態内
-
Miura Toshiro
Department Of Medicine And Clinical Science Division Of Cardiology Yamaguchi University Graduate Sch
-
Kametani Ryousuke
Division Of Cardiovascular Medicine Department Of Medical Bioregulation Yamaguchi University School
-
Ikeda Yasuhiro
Dept. Of Medical Bioregulation Division Of Cardioventricular Medicine Yamaguchi University School Of
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Matsui Toshihiro
Department Of Rheumatology National Hospital Organization Sagamihara Hospital
-
Miyazaki Tsuyoshi
Department Of Rheumatology Sagamihara National Hospital National Hospital Organization (nho)
-
Miura T.
Second Department Of Internal Medicine Yamaguchi University School Of Medicine
-
Dairaku Yuka
Division Of Cardiovascular Medicine The Department Of Medical Bioregulation Yamaguchi University Sch
-
Okamura Takayuki
Division Of Cardiology Department Of Medicine And Clinical Science Yamaguchi University Graduate Sch
-
Ikeda Yasuhiro
Department Of Cardiovascular Medicine Yamaguchi University
-
Kimura Masayasu
Deparment Of Chemical Pharmacology Faculty Of Pharmaceutical Sciences Toyama Medical And Pharmaceuti
-
Miura Toshiro
Department Of Cardiovascular Medicine Yamaguchi University Graduate School Of Medicine
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