Electronic Structure of Brain : Structure-Activity Relationships between Electronic Structure and Neurotransmitters Based on Molecular Hardness Concept
スポンサーリンク
概要
- 論文の詳細を見る
In order to understand the relation between the electronic structure of neurotransmitters and the brain, a model of the brain based on absolute hardness (η) and absolute electronegativity (χ) is described. It was found that the coordinate r (χ, η) of electronic structures of neurotransmitters obtained using the parameters η and χ can be graphically classified into three groups : catecholamine type (group I), gamma-aminobutanoic acid (GABA) type (group II), and acetylcholine (ACh) type (group III) in the η-χ diagram. The results suggest that the brainstem and neocortex in the brain are chemically soft and hard, respectively, because they show that the myelinated nerve is chemically soft and the unmyelinated nerve is chemically hard. If one calculates the r(χ, η) to understand which group a drug belongs to, one can predict the target receptors of the drug from the η-χ diagram. Using η-χ maps, one is then able to design medications like antidepressants, tranquilizers, and ACh agonists.
- 公益社団法人日本薬学会の論文
- 2004-05-01
著者
-
Kobayashi Shigeki
Department Of Analytical Chemistry Of Medicines Showa Phamaceutical University
-
Kobayashi Shigeki
Department Of Analytical Chemistry Of Medicines Showa Pharmaceutical University
-
Terao Y
Department Of Analytical Chemistry Of Medicines Showa Pharmaceutical University
-
TERAO Yuki
Department of Analytical Chemistry of Medicines, Showa Pharmaceutical University
関連論文
- PJ-573 Dantrolene Prevents Catecholaminergic Polymorphic Ventricular Tachycardia (CPVT) by Correcting Abnormal Ca^ Release through the Ryanodine Receptor(PJ096,Arrhythmia, Others (Clinical/Pathophysiology) 4 (A),Poster Session (Japanese),The 73rd Annu
- 3 Correction of RyR2 Defects as a New Therapeutic Strategy against Heart Failure(Novel Therapeutic Strategies against Heart Failure,KSC-JCS Joint Symposium (KSC-JCS Joint Symposium) (I),The 73rd Annual Scientific Meeting of The Japanese Circulation Societ
- Role of ryanodine receptor as a Ca^ regulatory center in normal and failing hearts
- Defective Ca^ Cycling as a Key Pathogenic Mechanism of Heart Failure(Molecular Mechanisms)
- FRS-018 Marked Increase in Spontaneous Ca2+ Sparks In Response To β-stimulation As A Critical Cause Of Catecholaminergic Polymorphic Ventricular Tachycardia(New Insights into Basic Mechanism of Arrhythmia(A),Featured Research Session,The 72nd Annual Scien
- PE-164 Defective Inter-domain Interaction may Cause Spontaneous Ca^ Release via Reduced Affinity of Calmodulin Binding to RyR2 in Failing Hearts(PE028,Heart Failure, Basic (M),Poster Session (English),The 73rd Annual Scientific Meeting of The Japanese
- 環境ホルモンの電子構造はその毒性や生物活性の発現にどのような相関性を持つのであろうか?-ハードネス概念の生物学への応用-
- Toxicity of Dioxins : Role of an Absolute Hardness-Adsolute Electronegativity Diagram (η-χ Diagram) as a New Measure in Risk Assessment
- Alkaloidal Constituents of Leucojum autumnale L. (Amaryllidaceae)
- Isolation and Structure Elucidation of a Novel Alkaloid, Incartine, a Supposed Biosynthetic Intermediate, from Flowers of Lycoris incarnata
- Alkaloidal Constituents of Hymenocallis rotata HERB. (Amaryllidaceae)(Organic,Chemical)
- Structures of Acid B and Related Compounds, Oxidation Products of Lycoramine
- Alkaloidal Constituents of Leucojum asetivum L. (Amaryllidaceae)
- Alkaloidal Constituents of Crinum latifolium and Crinum bulbispermum (Amaryllidaceae)
- Isolation of O-Demethyllycoramine from Bulbs of Lycoris radiata HERB.
- Transformation of Tazettine to Pretazettine
- Relationship between the Biological Potency of Polychlorinated Dibenzo-p-dioxins and Their Electronic States
- Isolation, Purification and Characterization of Cyclomaltooctadecaose (v-Cyclodextrin), Cyclomaltononadecaose (ζ-Cyclodextrin), Cyclomaltoeicosaose (o-Cyclodextrin) and Cyclomaltoheneicosaose (π-Cyclodextrin)
- Isolation, Purification, and Characterization of Cyclomaltotetradecaose (ι-Cyclodextrin), Cyclomaltopentadecaose (κ-Cyclodextrin), Cyclomaltohexadecaose (λ-Cyclodextrin), and Cyclomaltoheptadecaose(μ-Cyclodextrin)
- Complex Formation of Cyclomaltononaose δ-Cyclodextrin (δ-CD) with Macrocyclic Compounds
- Crystal Structure of Cyclomaltodecaose(ε-Cyclodextrin)at 203 K
- Isolation and Purification of Cyclomaltononaose (δ-CD) from CELDEX SG-30
- Isolation, Purification, and Characterization of Cyclomaltodecaose (ε-Cyclodextrin), Cyclomaltoundecaose (ζ-Cyclodextrin) and Cyclomaltotridecaose (θ-Cyclodextrin)
- Piperidine Carboxylic Acid Derivatives of 10H-Pyrazino[2,3-b][1,4] benzothiazine as Orally-Active Adhesion Molecule Inhibitors
- Inhibitors of Adhesion Molecules Expression : The Synthesis and Pharmacological Properties of 10H-Pyrazino [2,3-b] [1,4] benzothiazine Derivatives
- Development of New Double-Stranded Phenylalanyl Chelators Using η–χ Diagrams and Binding Constants for Chelators and Lanthanide Ions
- Isolation of N-Demethylgalanthamine from the Bulbs of Crinum asiaticum L. var. japanicum BAKER (Amaryllidaceae)
- Synthetic Studies of Zoanthamine/Norzoanthamine : Biogenetic-like One-Step Construction of the Heterocyclic Aminal Core (CDEFG Ring) from a Monocyclic Precursor
- Glycosyl 2-Pyridinecarboxylate as an Effective Glycosyl Donor : Glycosidation of Mannose, 2-Azidosugar, and 2-Deoxysugar into Disaccharides
- Diagnostic value of late gadolinium-enhanced MRI and first-pass dynamic MRI for predicting functional recovery in patients after acute myocardial infarction
- Synthesis of 2'-Cyanomethyl-2-biphenylcarboxylic Acid
- Synthesis, Conformation, and Chemical Properties of New Mini Parallel Double-Stranded Peptides Conjugated with -Phe-Phe- and -Phe-Phe-X- Sequences
- Diastereomer-Specific Effects of Double-Stranded Peptides Conjugated with-L-Tyr-L-Phe-or-L-Tyr-D-Phe-Residues on Tyrosine : Phosphorylation and Inhibition of src^NRK, A431, MCF-7, and DU145 Cell Growth
- Diastereomeric Selective Effects of Double-Stranded Peptides Conjugated with -Phe-Phe- Residue for Growth Inhibition and Permeability of Ca^ on A431, src^NRK, and A549 Cells Proliferation
- Development of Soft-Based Double-Stranded Peptide Chelators which Selectively Separate Europium and Lanthanum Ions Based on the Hardness Concept(Communications to the Editor)
- Development of Functional Double-stranded Peptide Chelators Which Selectively Separate Europium and Lanthanum Ions
- Cerebral Vein Disorders and Postoperative Brain Damage Associated with the Pterional Approach in Aneurysm Surgery
- DNA Topology on an Increase in Positive Writhing Number of DNA : Conformation Changes in the Time Course of cis-Diamminedichloroplatinum(II)-DNA Adducts
- Dantrolene, a Therapeutic Agent for Malignant Hyperthermia, Inhibits Catecholaminergic Polymorphic Ventricular Tachycardia in a RyR2^ Knock-In Mouse Model
- Fluid Motion Induced by Gravitational Differentiation of Immiscible Two Phases: Basic Equations and Linear Analyses
- Prediction of Endocrine Disruptors Based on a New Structure-Activity Relationship for Sex and Environmental Hormones Using Chemical Hardness Concept
- Diastereomeric Selective Effects for Growth Inhibition of Synthesized Mini Parallel Double-Stranded Peptides on Escherichia coli and Staphylococcus aureus
- Topology Effect for DNA Structure of Cisplatin : Topological Transformation of Cisplatin-Closed Circular DNA Addusts by DNA Topoisomerase I
- Hardness Controlled Enzymes and Electronegativity Controlled Enzymes : Role of an Absolute Hardness-Electronegativity (η-χ) Activity Diagram as a Coordinate for Biological Activities
- Formation of Pyrido[3,2-f]quinoxalines by Reaction of 6-Amino-2,3-dimethylquinoxaline with Aldehydes
- Stereo Structure-Controlled and Electronic Structure-Controlled Estrogen-Like Chemicals to Design and Develop Non-estrogenic Bisphenol A Analogs Based on Chemical Hardness Concept
- Isolation of Clivacetine from Clivia miniata REGEL. (Amaryllidaceae)
- Isolation of Carinatine and Pretazettine from the Bulbs of Zephyranthes carinate HERB. (Amaryllidaceae)
- Ruptured Cerebral Aneurysm Associated with Coarctation of the Aorta : Report of Two Cases
- Electronic Structure of Brain : Structure-Activity Relationships between Electronic Structure and Neurotransmitters Based on Molecular Hardness Concept
- Lectin Histochemical Evaluation of Rat Sciatic Nerve after Glycerol Injection : Observation at Chronic Stage
- A case of mitochondrial disease with severe left ventricular hypertrophy
- Electrical and Optical Control of Ferromagnetism in III-V Semiconductor Heterostructures at High Temperature (${\sim}100$ K)
- Recent Trends in Neuroendovascular Therapy in Japan: Analysis of a Nationwide Survey—Japanese Registry of Neuroendovascular Therapy (JR-NET) 1 and 2