Complex Formation of Cyclomaltononaose δ-Cyclodextrin (δ-CD) with Macrocyclic Compounds
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概要
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The complex forming ability of δ-cyclodextrin δ-CD with 7 kinds of macrocyclic compounds (MCCs) with 8-15 carbon atoms in the ring as models of large guest molecules was studied in aqueous solution and compared with the complexation properties of α-, β- and γ-CD. Both α- and β-CD formed relatively stable complexes with small MCCs, while γ- and δ-CD were more efficient in binding larger MCCs. The solid MCC/δ-CD complexes were precipitated with the larger MCCs with 11-15 carbon atoms in the ring, while no such precipitates were obtained with smaller MCCs with only 8-10 carbon atoms in the ring. The formation of the solid complexes was confirmed by powder X-ray diffractometry and differential scanning calorimetry. The cell dimensions of cycloundecanone (11 carbon atoms in the ring)/δ-CD complex were determined by X-ray crystallography. The preliminary crystal data were : Monoclinic, P2_1,a=32.50 (2) Å, b=19.02 (3) Å, c=16.60 (1) Å, β=98.37 (5)°, V=10148 (16) Å^3.
- 社団法人日本薬学会の論文
- 2000-12-01
著者
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Nagase Hidetaka
大鵬薬品工業
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Endo T
Graduate School Of Pharmaceutical Sciences Hokkaido University
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Endo T
Department Of Physical Chemistry Hoshi University
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Endo Tomohiro
Department of Materials, Physics and Energy Engineering, Nagoya University
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Ueda H
Faculty Of Pharmaceutical Sciences Josai University
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NAGASE Hiromasa
Department of Physical Chemistry, Hoshi University
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UEDA Haruhisa
Department of Physical Chemistry, Hoshi University
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AKASAKA Hiroki
Department of Physical Chemistry, Hoshi University
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KOBAYASHI Shoichi
Laboratory of Food and Health Science, Department of Agro-bioscience, Faculty of Agriculture, Iwate
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Ueda H
Kyoto Pharmaceutical University
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Kobayashi S
Eisai Research Institute Of Boston Inc.
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Ueda H
Hoshi Univ. Tokyo Jpn
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Ueda H
Department Of Physical Chemistry Hoshi University
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Ueda H
Faculty Of Pharmaceutical Sciences Hoshi University
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Ueda Haruhisa
Research Institute For Scientific Measurements Tohoku University
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Ueda Haruhisa
Faculty Of Pharmaceutical Science Hoshi University
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Ueda Haruhisa
Department Of Physical Chemistry Hoshi University
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Kobayashi Shoichi
Laboratory Of Food And Health Science Department Of Agro-bioscience Faculty Of Agriculture Iwate Uni
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Ueda Hideo
Fac. Of Pharmaceutical Sciences Josai Univ.
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Kobayashi Shigeki
Department Of Analytical Chemistry Of Medicines Showa Phamaceutical University
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Ueda H
Fac. Of Pharmaceutical Sciences Josai Univ.
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Kobayashi Shigeki
Department Of Analytical Chemistry Of Medicines Showa Pharmaceutical University
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上田 仁司
Kawanishi Pharma Research Institute Nippon Boehringer Ingelheim Co. Ltd.
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Akasaka H
Department Of Physical Chemistry Hoshi University
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Kobayashi Shigeki
Div. Of Analytical Chemistry Of Medicines Showa Pharmaceutical Univ.
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Nagase H
Pharmacobioregulation Research Laboratory Taiho Pharmaceutical Co. Ltd.
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Akasaka Hiroki
Department Of Chemistry Nagaoka University Of Technology
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Endo Tomohiro
Department Of Material Physics And Energy Engineering Graduate School Of Engineering Nagoya Universi
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Endo Tomohiro
Department Of Functional Radiation Sciences Hoshi University
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