Influence of Skin Hydration on Anesthetic Effect of Lidocaine Tape in Hemodialysis Patients
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概要
- 論文の詳細を見る
We surveyed the current use of lidocaine tape in hemodialysis (HD) patients and evaluated the condition of their skin. Nearly 80% of them complained of pain on needle insertion, and the evaluation of their skin condition indicated that the stratum corneum moisture content was significantly lower than that of healthy volunteers. In view of this, we investigated skin hydration as a simple method of enhancing lidocaine absorption in HD patients. Skin hydration reduced the amount of pain on needle insertion in half of the 16 HD patients. It stayed about the same or increased slightly in the other half. To examine the effect of skin hydration in more detail, we investigated lidocaine concentrations in porcine ear skin and found that the skin lidocaine concentrations were significantly increased (8.97±2.44μg/cm^2 vs. 24.51±12.26μg/cm^2 after 30min of application) by skin hydration. We feel that it could be an effective means of alleviating the pain experienced by HD patients.
- 日本医療薬学会の論文
- 2008-11-10
著者
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UEDA Hideo
Department of Pharmaceutics, Faculty of Pharmaceutical Sciences, Josai University
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NUMAJIRI Sachihiko
Department of Pharmaceutics, Faculty of Pharmaceutical Sciences, Josai University
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Sasaki Hiromi
Department of Cardiology, Ogaki Municipal Hospital
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Ueda H
Faculty Of Pharmaceutical Sciences Josai University
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Ueda H
Kyoto Pharmaceutical University
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森本 泰子
Department Of Pharmaceutics Faculty Of Pharmaceutical Sciences Kobe Gakuin University
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Kimura Soichiro
Department Of Microbiology And Infectious Disease Toho University School Of Medicine
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Kimura Soichiro
Department Of Hospital Pharmacy Faculty Of Pharmaceutical Sciences Josai University
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Morimoto Y
Josai Univ. Saitama Jpn
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Morimoto Y
Faculty Of Pharmaceutical Sciences Josai University:research Institute Of Tts Technology
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Morimoto Yasunori
Fac. Of Pharmaceutical Sciences Josai Univ.
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Morimoto Yasunori
Department Of Hospital Pharmacy Faculty Of Pharmaceutical Sciences Josai University
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Ueda H
Hoshi Univ. Tokyo Jpn
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Ueda H
Department Of Physical Chemistry Hoshi University
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Ueda H
Faculty Of Pharmaceutical Sciences Hoshi University
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Ueda Haruhisa
Research Institute For Scientific Measurements Tohoku University
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Ueda Haruhisa
Faculty Of Pharmaceutical Science Hoshi University
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Ueda Hideo
Fac. Of Pharmaceutical Sciences Josai Univ.
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NUMAJIRI SACHIHIKO
Faculty of Pharmaceutical Sciences, Josai University
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Ooi Kazuya
(現)鈴鹿医療科学大学薬学部病態・治療学分野臨床薬理学研究室
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Yoshizawa Naoki
Department of Hospital Pharmacy, Faculty of Pharmaceutical Sciences, Josai University
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Sugawa Tetsushi
Department of Hospital Pharmacy, Faculty of Pharmaceutical Sciences, Josai University
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Kojima Saori
Department of Pharmacy, Yokkaichi Social Insurance Hospital
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Katayama Toshiya
Department of Pharmacy, Yokkaichi Social Insurance Hospital
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Mizutani Yasuhide
Department of Nephrology, Yokkaichi Social Insurance Hospital
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Yoshizawa Naoki
Department Of Hospital Pharmacy Faculty Of Pharmaceutical Sciences Josai University
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Morimoto Yasunori
Faculty Of Pharmaceutical Sciences Josai University:research Institute Of Tts Technology
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Ueda H
Fac. Of Pharmaceutical Sciences Josai Univ.
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上田 仁司
Kawanishi Pharma Research Institute Nippon Boehringer Ingelheim Co. Ltd.
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Kojima Saori
Department Of Pharmacy Yokkaichi Social Insurance Hospital
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Seto Hiroki
Fac. Of Pharmaceutical Sciences Josai Univ.
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Sugawa Tetsushi
Department Of Hospital Pharmacy Faculty Of Pharmaceutical Sciences Josai University
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Numajiri S
Department Of Hospital Pharmacy Faculty Of Pharmaceutical Sciences Josai University
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Numajiri Sachihiko
Department Of Pharmaceutics Faculty Of Pharmaceutical Sciences Josai University
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Katayama Toshiya
Department Of Pharmacy Yokkaichi Social Insurance Hospital
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Ueda Hideo
Department Of Computer Science And Electronics Kyushu Institute Of Technology
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Mizutani Yasuhide
Department Of Nephrology Yokkaichi Social Insurance Hospital
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