The Enhancing Effect of a Triethanolamine-Ethanol-Isopropyl Myristate Mixed System on the Skin Permeation of Acidic Drugs(Biopharmacy)
スポンサーリンク
概要
- 論文の詳細を見る
The effect of a TEI enhancer mixed system consisting of triethanolamine (T), ethanol (E) and isopropyl myristate (IPM) on the skin permeation of acidic, basic and neutral drugs were evaluated in vitro using excised hairless rat skin. The binary enhancer system consisting of IPM and ethanol (EI) produced marked improvement on the penetration of all the drugs tested. When T was added to the EI system, a greater enhancing effect was found only on acidic drugs with a carboxyl group, compared with the flux in the EI system. On addition of another amine to the EI system, instead of T, mefenamic acid (MA), which exhibited the highest enhancing effect of the model drugs, showed an approximately 14-180 times greater flux than when delivered by the El system. On simultaneous application of isosorbide dinitrate (ISDN) with MA in the TEI system, the flux of MA increased on increasing the T concentration in the TEI system, while, the flux of ISDN, a neutral drug, was unaffected by the T concentration. Application of MA in the EI system after pretreatment of the TEI system showed that the residual amount of T in the skin plays an important role in the skin permeation of MA. Furthermore, at a fixed concentration of MA, the flux of MA increased on increasing the T concentration in the TEl system, while the flux of E remained unchanged. Finally, the infrared spectrum of MA with amine in the E solution indicated that the carboxyl group of MA was ionized. These results demonstrated that the formation of an ion pair between MA and T, but not the effect of T on the skin, may be responsible for the enhanced skin permeation of MA using the TEI system.
- 公益社団法人日本薬学会の論文
- 2002-10-01
著者
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Sugibayashi Kenji
Faculty of Pharmaceutical Sciences, Josai University
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Morimoto Yasunori
Faculty of Pharmaceutical Sciences, Josai University
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Kobayashi D
Fac. Of Pharmaceutical Sciences Josai Univ.
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森本 泰子
Department Of Pharmaceutics Faculty Of Pharmaceutical Sciences Kobe Gakuin University
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Morimoto Y
Josai Univ. Saitama Jpn
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Morimoto Y
Faculty Of Pharmaceutical Sciences Josai University:research Institute Of Tts Technology
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Morimoto Yasunori
Fac. Of Pharmaceutical Sciences Josai Univ.
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Morimoto Yasunori
Department Of Hospital Pharmacy Faculty Of Pharmaceutical Sciences Josai University
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Morimoto Yasunori
Faculty Of Pharmaceutical Sciences Josai University
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KOBAYASHI Daisuke
Faculty of Pharmaceutical Sciences, Josai University
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NUMAJIRI SACHIHIKO
Faculty of Pharmaceutical Sciences, Josai University
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FANG Liang
Faculty of Pharmaceutial Sciences, Josai University
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KOBAYASHI Yoichi
Toko Pharmaceutical Ind. Co., Ltd.
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Morimoto Yasunori
Faculty Of Pharmaceutical Sciences Josai University:research Institute Of Tts Technology
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Sugibayashi Kenji
Faculty Of Pharmaceutial Sciences Josai University
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Sugibayashi Kenji
Faculty Of Pharmaceutical Sciences Josai University:research Institute Of Tts Technology
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Sugibayashi Kenji
Fac. Of Pharmaceutical Sciences Josai Univ.
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Sugibayashi Kenji
Josai-university Faculty Of Pharmaceutical Sciences
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Sugibayashi Kenji
Department Of Neuropathology Tokyo Metropolitan Institute For Neurosciences
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Sugibayashi K
Faculty Of Pharmaceutical Sciences Josai University:life Science Research Center Josai University
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Fang Liang
Department Of Materials Science And Engineering Faculty Of Engineering Kyushu Institute Of Technolog
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Fang Liang
Faculty Of Pharmaceutial Sciences Josai University
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SUGIE Kenichi
Josai-University faculty of pharmaceutical sciences
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Numajiri S
Department Of Hospital Pharmacy Faculty Of Pharmaceutical Sciences Josai University
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Kobayashi Yoichi
Toko Pharmaceutical Ind. Co. Ltd.
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Kobayashi Daisuke
Fac. Of Pharmaceutical Sciences Josai Univ.
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