ANTITUMOR AGENT POLY (AMINO ACID) CONJUGATES AS A DRUG CARRIER IN CANCER CHEMOTHERAPY
スポンサーリンク
概要
- 論文の詳細を見る
Antitumor agent melphalan was conjugated through a carbodiimide-catalyzed reaction to poly (L-lysine) (71.3K and 2K) and poly (L-glutamic acid) (60K and 14K) at a ratio of approximately one molecule per 7-lysyl and 23-glutamate residues, respectively. These conjugates had 40-70% of alkylating activities by themselves in vitro as compared with free melphalan. Poly (glutamic acid) conjugates showed the antitumor activity in vivo against Yoshida sarcoma in rats. In addition, poly (glutamic acid) conjugates containing ^3H-phenylalanine which was used as a model compound instead of melphalan had a sustained release property of radioactivity and the release rates could be regulated by exopeptidases. After subcutaneous injection as the first choice of routes of administration, moreover, the conjugates were found to be absorbed through the lymphatic transport system, probably due to the macromolecularity. These results suggest that the melphalan-poly (amino acid) conjugates are one of good candidates to attain the sustained release and targeting of drugs in cancer chemotherapy.
- 公益社団法人日本薬学会の論文
著者
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Morimoto Yasunori
Faculty of Pharmaceutical Sciences, Josai University
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OGAWA Yoshihiro
Department of Radiation Oncology, Tohoku University, Graduate School of Medicine
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Morimoto Y
Faculty Of Pharmaceutical Sciences Josai University:research Institute Of Tts Technology
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Morimoto Yasunori
Fac. Of Pharmaceutical Sciences Josai Univ.
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Morimoto Yasunori
Department Of Hospital Pharmacy Faculty Of Pharmaceutical Sciences Josai University
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Morimoto Yasunori
Faculty Of Pharmaceutical Sciences Josai University
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HOSOYA Ken-ichi
Department of Molecular Biopharmacy and Genetics, Graduate School of Pharmaceutical Sciences, Tohoku
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SUGIBAYASHI Kenji
Department of Pharmaceutics, Faculty of Pharmaceutical Sciences
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SUGIHARA SATOSHI
Department of Neuropathology, Tokyo Metropolitan Institute for Neurosciences
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NOZAKI SUKEKATSU
Department of Neuropathology, Tokyo Metropolitan Institute for Neurosciences
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Morimoto Yasunori
Faculty Of Pharmaceutical Sciences Josai University:research Institute Of Tts Technology
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Sugibayashi Kenji
Faculty Of Pharmaceutial Sciences Josai University
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Sugibayashi Kenji
Faculty Of Pharmaceutical Sciences Josai University:research Institute Of Tts Technology
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Sugibayashi Kenji
Fac. Of Pharmaceutical Sciences Josai Univ.
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Sugibayashi Kenji
Josai-university Faculty Of Pharmaceutical Sciences
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Sugibayashi Kenji
Department Of Neuropathology Tokyo Metropolitan Institute For Neurosciences
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Ogawa Yoshihiro
Department Of Applied Life Sciences Niigata University Of Pharmacy And Applied Life Sciences
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Sugibayashi K
Faculty Of Pharmaceutical Sciences Josai University:life Science Research Center Josai University
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Hosoya Ken-ichi
Department Of Molecular Biopharmacy And Genetics Graduate School Of Pharmaceutical Sciences Tohoku U
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Sugihara Satoshi
Department Of Neuropathology Tokyo Metropolitan Institute For Neurosciences
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SUGIE Kenichi
Josai-University faculty of pharmaceutical sciences
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Ogawa Yoshihiro
Department Of Neuropathology Tokyo Metropolitan Institute For Neurosciences
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Nozaki Sukekatsu
Department Of Neuropathology Tokyo Metropolitan Institute For Neurosciences
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Nozaki Sukekatsu
Department of Chemistry, College of Science, Rikkyo University
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