Difference in the Enhancing Effects of Ultrasound on the Skin Permeation of Polar and Non-polar Drugs
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概要
- 論文の詳細を見る
The effect of ultrasound (150kHz, 111mW/cm^2) on the permeability of isosorbide dinitrate (ISDN) and antipyrine (ANP) through excised hairless rat skin was evaluated using an Arrhenius plot. The permeability coefficients of ISDN across skin (at various temperatures) in the presence and absence of ultrasound were virtually isolinear on the Arrhenius plot, It has been suggested that the temporal increase in the ISDN flux, which was observed when ultrasound was applied in our previous study, was only a result of the thermal effect of ultrasound, i.e. an increase in the temperature of the donor solution. On the other hand, ultrasound influenced the Arrhenius plot of ANP, suggesting that the enhancement effect for ANP permeation could be not explained only by the thermal effect of ultrasound. In addition, the effective diffusion (D) and partitio coefficients (K) of ISDN and ANP were estimated using their skin permeation profiles across the ultrasonic pretreated skin. The coefficients of ISDN with ultrasonic pretreatment were comparable to those without pretreatment. On the other hand, the D value of ANP with ultrasonic pretreatment was increased about 4 times by ultrasonic pretreatment, in spite of an insignificant change in the K value. These results suggest that the ultrasound used in the present study increased the effective diffusivity across the aqueous region in the stratum corneum to enhance the skin permeation of the polar compound, ANP.
- 公益社団法人日本薬学会の論文
- 1996-10-15
著者
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Sugibayashi Kenji
Faculty of Pharmaceutical Sciences, Josai University
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Morimoto Yasunori
Faculty of Pharmaceutical Sciences, Josai University
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Ueda H
Faculty Of Pharmaceutical Sciences Josai University
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Ueda Hideo
Faculty of Pharmaceutical Sciences, Josai University
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Morimoto Yasunori
Faculty Of Pharmaceutical Sciences Josai University
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Morimoto Y
Faculty Of Pharmaceutical Sciences Josai University:life Science Research Center Josai University
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OGIHARA Masahiko
Faculty of Pharmaceutical Sciences, Josai University
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Sugibayashi Kenji
Faculty Of Pharmaceutical Sciences Josai University:life Science Research Center Josai University
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Sugibayashi Kenji
Faculty Of Pharmaceutial Sciences Josai University
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Ogihara M
Josai Univ. Saitama Jpn
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Ueda Hideo
Faculty Of Pharmaceutical Sciences Josai University
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