Relationships between the Particle Velocity and Introduction of Drug-Loaded Microparticles into the Skin in a Microparticulate Bombardment System
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概要
- 論文の詳細を見る
Recently, it has been suggested that a microparticulate bombardment system would be a very useful tool for the delivery of a variety of powdered drugs as an alternative to parenteral injection via a needle. However the relationship between the particle dynamics and introduction into the skin has not been researched using this system. In the present study, we analyzed the velocity of microparticles bombarded by the HeliosTM gun system under various conditions using particle image velocimetry (PIV). The particle kinetic energy, which depended on the particle velocity and particle mass, was increased with increasing helium pressure and particle size, decreasing bombardment dose, resulting in the increased percentage introduction and relative bioavailability (F0—24 h). The particle velocity had a greater influence than the particle mass. Therefore, in order to be the most effective system for introduction into the skin, it is necessary to use a high helium pressure and microparticles of high density. However, it is also necessary to consider the skin damage after bombardment.
- 公益社団法人 日本薬学会の論文
著者
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Morimoto Yasunori
Faculty of Pharmaceutical Sciences, Josai University
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Uchida Masaki
Faculty Of Pharmaceutical Sciences Josai University
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Seki T
Department Of Pharmaceutics Graduate School Of Pharmaceutical Sciences Hokkaido Pharmaceutical Unive
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Seki Toshinobu
Hokkaido Pharmaceutical University School Of Pharmacy
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Seki Toshinobu
Faculty Of Pharmaceutical Sciences Josai University
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Morimoto Yasunori
Faculty Of Pharmaceutical Sciences Josai University
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Seki T
Hokkaido Pharmaceutical University School Of Pharmacy
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NATSUME Hideshi
Faculty of Pharmaceutical Sciences, Josai University
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Uchida Masaatsu
Departments Of Pharmacology Meiji Pharmaceutical University
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Uchida Mihoko
Department Of Biochemistry Faculty Of Pharmaceutical Sciences Hoshi University
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Uchida M
Otsuka Pharmaceutical Co. Ltd. Tokushima Jpn
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Natsume Hideshi
Faculty Of Pharmaceutical Sciences Josai University:research Institute Of Tts Technology
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Uchida Tateki
School of Science & Engineering, Tokyo Denki University
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Seki Toshinobu
Faculty of Pharmaceutical Sciences, Josai University
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Uchida Masaki
Faculty of Pharmaceutical Sciences, Josai University
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Uchida Tateki
School of Science & Engineering, Tokyo Denki University
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