Synthesis and Antibacterial Activity of the Metabolites of 9-Fluoro-6,7-dihydro-8-(4-hydroxy-1-piperidyl)-5-methyl-1-oxo-1H, 5H-benzo[i, j]quinolizine-2-carboxylic Acid (OPC-7251)

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概要

• 論文の詳細を見る

• The metabolites of 9-fluoro-6,7-dihydro-8-(4-hydroxy-1-piperidyl)-5-methyl-1-oxo-1H, 5H-benzo[i, j]quinolizine-2-carboxylic acid (OPC-7251) (1), which has a potent antiabacterial activity against gram-positive bacteria, characteristically Propionibacterium acnes, were synthesized to confirm their structures and to examine their antibacterial activity. The structures of three major metabolites (2,3a and 4) were identified by means of comparison with the synthetic compounds. The antibacterial activity of the metabolites (2,3a and 4) was found to be lower than that of 1.

• 社団法人日本薬学会の論文
• 1990-07-25

著者

• 清水 剛文

  Tokushima Research Institute Otsuka Pharmaceutical Co. Ltd.

• 玉岡 寿

  Tokushima Research Institute Otsuka Pharmaceutical Co. Ltd.

• 内多 稔

  Tokushima Research Institute, Otsuka Pharmaceutical Co., Ltd.,

• 森田 清司

  Tokushima Research Institute, Otsuka Pharmaceutical Co., Ltd.,

• 大坪 健児

  Tokushima Research Institute, Otsuka Pharmaceutical Co., Ltd.,

• Morita S

  Tokushima Research Institute Otsuka Pharmaceutical Co. Ltd.

• Uchida Masaki

  Faculty Of Pharmaceutical Sciences Josai University

• 河端 繁勝

  Tokushima Research Institute, Otsuka Pharmaceutical Co., Ltd.,

• Uchida Masaatsu

  Departments Of Pharmacology Meiji Pharmaceutical University

• 河端 繁勝

  Tokushima Research Institute Otsuka Pharmaceutical Co. Ltd.

• Uchida Mihoko

  Department Of Biochemistry Faculty Of Pharmaceutical Sciences Hoshi University

• Morita S

  Kagawa Medical Univ. Kagawa Jpn

• Uchida M

  Otsuka Pharmaceutical Co. Ltd. Tokushima Jpn

• Morita Shushi

  Department Of Hospital Pharmacy Kagawa University

• 大坪 健児

  Tokushima Research Institute Otsuka Pharmaceutical Co. Ltd.

• 森田 清司

  Tokushima Research Institute Otsuka Pharmaceutical Co. Ltd.

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