Synthesis of Metabolites of the Cerebroprotecting Agent 7-Hydroxy-1-[[[4-(3-methoxyphenyl)-1-piperazinyl]acetyl]amino]-2,2,4,6-tetramethylindan (OPC-14117)

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概要

• 論文の詳細を見る

• A hydroxylated metabolite (5a) of 7-hydroxy-1-[[[4-(3-methoxyphenyl)-1-piperazinyl]acetyl]amino]-2,2,4,6-tetramethylindan (OPC-14117), which is a novel cerebroprotective agent with central nervous system-stimulating activity, was synthesized by use of a model cytochrome P-450 system. In order to confirm the structure of this compound it was prepared by another route. The structures of several metabolites (5a, 7 and 8) were identified by means of comparisons with the synthetic compounds.

• 公益社団法人日本薬学会の論文
• 1997-04-15

著者

• Uchida Masaki

  Faculty Of Pharmaceutical Sciences Josai University

• 大谷 直明

  Tokushima Research Institute Otsuka Pharmaceutical Co. Ltd.

• Uchida Masaatsu

  Departments Of Pharmacology Meiji Pharmaceutical University

• Uchida M

  Otsuka Pharmaceutical Co. Ltd. Tokushima Jpn

• 大坪 健児

  Tokushima Research Institute Otsuka Pharmaceutical Co. Ltd.

• OTSUBO Kenji

  Tokushima Research Institute Otsuka Pharmaceutical Co., Ltd.,

• MATSUBARA Jun

  Tokushima Research Institute Otsuka Pharmaceutical Co., Ltd.,

• KITANO Kazuyoshi

  Tokushima Research Institute Otsuka Pharmaceutical Co., Ltd.,

• KAWANO Yoshikazu

  Tokushima Research Institute Otsuka Pharmaceutical Co., Ltd.,

• OHTANI Tadaaki

  Tokushima Research Institute Otsuka Pharmaceutical Co., Ltd.,

• MORITA Seiji

  Tokushima Research Institute Otsuka Pharmaceutical Co., Ltd.,

• SATO Seiji

  Third Institute of New Drug Research, Otsuka Pharmaceutical Co., Ltd.,

• OSHIRO Yasuo

  Third Institute of New Drug Research, Otsuka Pharmaceutical Co., Ltd.,

• UCHIDA Minoru

  Tokushima Research Institute Otsuka Pharmaceutical Co., Ltd.,

• Oshiro Y

  Third Institute Of New Drug Research Otsuka Pharmaceutical Co. Ltd.

• Ohtani T

  Minase Research Institute Ono Pharmaceutical Co. Ltd.

• Uchida Minoru

  Tokushima Research Institute Otsuka Pharmaceutical Co. Ltd.

• Sato Seiji

  Third Institute Of New Drug Research Otsuka Pharmaceutical Co. Ltd.

• Morita Seiji

  Tokushima Research Institute Otsuka Pharmaceutical Co. Ltd.

• Kawano Y

  Otsuka Pharmaceutical Co. Ltd. Tokushima Jpn

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