Discovery of New Orally Active Phosphodiesterase (PDE4) Inhibitors
スポンサーリンク
概要
- 論文の詳細を見る
A series of 4-anilinopyrazolopyridine derivatives were synthesized and biologically evaluated as inhibitors of phosphodiesterase (PDE4). Chemical modification of 3, a structurally new chemical lead that was found in our in-house library, was focused on 1- and 3-substituents. Full details of the discovery of a new orally active chemical lead 5 are presented. Structure-activity relationship data, pharmacological evaluation, and the subtype selectivity study are also presented.
- 公益社団法人日本薬学会の論文
- 2004-09-01
著者
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KUSUMI Kensuke
Department of Biology, Faculty of Science, Kyushu University
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Nakai H
Analytical Research Laboratory Tanabe Seiyaku Co. Ltd.
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Kusumi K
Department Of Biology Faculty Of Science Kyushu University
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Kusumi Kensuke
Department Of Biology Kyushu University
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Kusumi Kensuke
Department Of Biology Faculty Of Science Kyushu University
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Kusumi Kensuke
Minase Research Institute Ono Pharmaceutical Co. Ltd.
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Kusumi Kensuke
Department Of Biology Faculty Of Sciences Kyushu University
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Obata Tohru
Department Of Experimental Therapeutics Cancer Research Institute Kanazawa University
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大谷 直明
Tokushima Research Institute Otsuka Pharmaceutical Co. Ltd.
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Obara Takumi
Department Of Experimental Therapeutics Cancer Research Institute Kanazawa University
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Ochiai H
Minase Research Institute Ono Pharmaceutical Co. Ltd.
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OCHIAI Hiroshi
Minase Research Institute, Ono Pharmaceutical Co., Ltd.
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ISHIDA Akiharu
Minase Research Institute, Ono Pharmaceutical Co., Ltd.
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OHTANI Tazumi
Minase Research Institute, Ono Pharmaceutical Co., Ltd.
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KISHIKAWA Katuya
Development Planning, Ono Pharmaceutical Co., Ltd.
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YAMAMOTO Susumu
Minase Research Institute, Ono Pharmaceutical Co., Ltd.
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TAKEDA Hiroshi
Minase Research Institute, Ono Pharmaceutical Co., Ltd.
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OBATA Takaaki
Minase Research Institute, Ono Pharmaceutical Co., Ltd.
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NAKAI Hisao
Minase Research Institute, Ono Pharmaceutical Co., Ltd.
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TODA Masaaki
Minase Research Institute, Ono Pharmaceutical Co., Ltd.
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Toda Masaaki
Minase Research Institute Ono Pharmaceutical Co. Ltd.
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Obata Takaaki
Department Of Experimental Therapeutics Cancer Research Institute Kanazawa University
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Ishida A
Minase Research Institute Ono Pharmaceutical Co. Ltd.
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Takeda H
Minase Research Institute Ono Pharmaceutical Co. Ltd.
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Nakai H
Minase Research Institute Ono Pharmaceutical Co. Ltd.
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Kishikawa Katuya
Development Planning Ono Pharmaceutical Co. Ltd.
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Ohtani T
Minase Research Institute Ono Pharmaceutical Co. Ltd.
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Takeda Hiroshi
Minase Research Institute Ono Pharmaceutical Co. Ltd.
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Ochiai Hiroshi
Minase Research Institute Ono Pharmaceutical Co. Ltd.
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Yamamoto Susumu
Minase Research Institute Ono Pharmaceutical Co. Ltd.
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