A Novel Preparation Method for Microspheres of Water Soluble Polymers Using Polypropyleneglycol as the Dispersion Medium
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概要
- 論文の詳細を見る
Polypropyleneglycol (PPG) was used as a dispersion medium for the preparation of microspheres (MS) consisting of starch, gelatin, whey protein or dextran. Aqueous solutions of the polymers were dispersed in PPG at various initial temperatures and then the systems were cooled to 0.5℃ to allow water in the dispersed phase to dissolve in PPG. The particle size of the starch-MS was dependent on the initial temperature of PPG in the preparation process. There were two different processes for particle generation in the procedure. One of them was via the formation of a temporary emulsion during the early phase of dispersion of the aqueous polymer solution into PPG. The other was via the stable emulsion in which the aqueous polymer solution was dispersed in water-saturated PPG. The particle size generated in the former process was dependent on the initial temperature : a high temperature gave large particles but a low temperature gave small particles, while that in the latter process was temperature-independent. This preparation method for MS will be useful for the formulation of heat-sensitive material, such as protein-containing drugs.
- 公益社団法人日本薬学会の論文
- 2007-03-01
著者
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Morimoto Kazuhiro
Hokkaido Pharmaceutical University School of Pharmacy
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Juni Kazuhiko
Faculty of Pharmaceutical Sciences, Josai University
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Uchida Masaki
Faculty Of Pharmaceutical Sciences Josai University
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Juni K
Faculty Of Pharmaceutical Sciences Josai University
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Juni Kazuhiko
北海道薬科大学
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從二 和彦
Faculty Of Pharmaceutical Sciences Josai University
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Juni Kazuhiko
Faculty Of Pharmaceutical Sciences Hokkaido University
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Seki T
Department Of Pharmaceutics Graduate School Of Pharmaceutical Sciences Hokkaido Pharmaceutical Unive
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Seki Toshinobu
Hokkaido Pharmaceutical University School Of Pharmacy
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Seki T
Department Of Nutrition And Physiology Nihon University College Of Bioresource Sciences
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Seki T
Hokkaido Pharmaceutical University School Of Pharmacy
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SHINOHARA Katsunori
Faculty of Pharmaceutical Sciences, Josai University
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KATO Naoko
Faculty of Pharmaceutical Sciences, Josai University
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NATSUME Hideshi
Faculty of Pharmaceutical Sciences, Josai University
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Uchida Masaatsu
Departments Of Pharmacology Meiji Pharmaceutical University
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Morimoto Kazuhiro
Department Of Pharmaceutics Graduate School Of Pharmaceutical Sciences Hokkaido Pharmaceutical Unive
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Morimoto K
Hokkaido Pharmaceutical University School Of Pharmacy
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Natsume Hideshi
Faculty Of Pharmaceutical Sciences Josai University:research Institute Of Tts Technology
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夏目 秀視
Faculty of Pharmaceutical Sciences, Josai University
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Shinohara Katsunori
Faculty Of Pharmaceutical Sciences Josai University
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Kato Naoko
Faculty Of Pharmaceutical Sciences Josai University
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内田 昌希
Faculty of Pharmaceutical Sciences, Josai University
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