EVALUATION OF A NEW SUSTAINED RELEASE THEOPHYLLINE FORMULATION BY THE MEASUREMENTS OF SALIVARY LEVELS OF THE DRUG IN HUMANS
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概要
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Dry agar beads containing theophylline were prepared. The release rate of theophylline from the agar beads in vitro was smaller than the dissolution rate of the drug from pure drug powders. The salivary levels of the drug following oral administration of the agar beads to three healthy volunteers were determined by reversed-phase high pressure liquid chromatography. Results of pharmacokinetic analyses indicated sustained absorption of the drug following the administration of the agar beads.
- 公益社団法人日本薬学会の論文
著者
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Juni Kazuhiko
Faculty Of Pharmaceutical Sciences Hokkaido University
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NAKANO MASAHIRO
Faculty of Pharmaceutical Sciences, Hokkaido University
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Nakamura Yuhko
Faculty Of Pharmaceutical Sciences Hokkaido University
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TOMITSUKA TOSHIAKI
Faculty of Pharmaceutical Sciences, Hokkaido University
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Tomitsuka Toshiaki
Faculty Of Pharmaceutical Sciences Hokkaido University
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Nakano Masahiro
Faculty Of Pharmaceutical Sciences Hokkaido University
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Nakano Masahiro
Faculty Of Pharmaceutical Sciences Hokkaido University:(present Address)department Of Pharmacy Kumam
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Nakano Masahiro
Faculty Of Health Sciences Junshin Gakuen University
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